[HTML][HTML] Enhancing autophagy in Alzheimer's disease through drug repositioning

M Eshraghi, M Ahmadi, S Afshar, S Lorzadeh… - Pharmacology & …, 2022 - Elsevier
Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …

The interaction between autophagy and JAK/STAT3 signaling pathway in tumors

J Xu, J Zhang, QF Mao, J Wu, Y Wang - Frontiers in Genetics, 2022 - frontiersin.org
Tumor is one of the important factors affecting human life and health in today's world, and
scientists have studied it extensively and deeply, among which autophagy and JAK/STAT3 …

[HTML][HTML] Repurposing Drugs in Oncology (ReDO)—chloroquine and hydroxychloroquine as anti-cancer agents

C Verbaanderd, H Maes, MB Schaaf… - …, 2017 - ncbi.nlm.nih.gov
Chloroquine (CQ) and hydroxychloroquine (HCQ) are well-known 4-aminoquinoline
antimalarial agents. Scientific evidence also supports the use of CQ and HCQ in the …

[HTML][HTML] 3, 5-Dicaffeoylquinic acid attenuates microglial activation-mediated inflammatory pain by enhancing autophagy through the suppression of MCP3/JAK2 …

J Park, Y Kim, C Lee, YT Kim - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Microglial activation in the spinal cord contributes to the development of inflammatory pain.
Monocyte chemotactic protein 3 (MCP3) can induce microglial activation, resulting in …

Phosphorylation of eukaryotic initiation factor-2α (eIF2α) in autophagy

J Humeau, M Leduc, G Cerrato, F Loos, O Kepp… - Cell death & …, 2020 - nature.com
The integrated stress response is characterized by the phosphorylation of eukaryotic
initiation factor-2α (eIF2α) on serine 51 by one out of four specific kinases (EIF2AK1 to 4) …

A brain proteomic signature of incipient Alzheimer's disease in young APOE ε4 carriers identifies novel drug targets

JA Roberts, VR Varma, Y An, S Varma, J Candia… - Science …, 2021 - science.org
Aptamer-based proteomics revealed differentially abundant proteins in Alzheimer's disease
(AD) brains in the Baltimore Longitudinal Study of Aging and Religious Orders Study (mean …

Increased autophagy is required to protect periodontal ligament stem cells from apoptosis in inflammatory microenvironment

Y An, W Liu, P Xue, Y Zhang… - Journal of Clinical …, 2016 - Wiley Online Library
Objective Autophagy, which provides a mechanism for turnover cellular organelles and
proteins through a lysosome‐dependent degradation pathway, has been related to the …

The role of endolysosomal trafficking in anticancer drug resistance

NA Hussein, S Malla, MA Pasternak, D Terrero… - Drug resistance …, 2021 - Elsevier
Multidrug resistance (MDR) remains a major obstacle towards curative treatment of cancer.
Despite considerable progress in delineating the basis of intrinsic and acquired MDR, the …

Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways

L Varisli, O Cen, S Vlahopoulos - Immunology, 2020 - Wiley Online Library
Chloroquines are 4‐aminoquinoline‐based drugs mainly used to treat malaria. At
pharmacological concentrations, they have significant effects on tissue homeostasis …

STAT3-targeted treatment with silibinin overcomes the acquired resistance to crizotinib in ALK-rearranged lung cancer

E Cuyas, A Pérez-Sánchez, V Micol, JA Menendez… - Cell Cycle, 2016 - Taylor & Francis
The signal transducer and activator of transcription 3 (STAT3) has been suggested to play a
prominent role in mediating non–small-cell lung cancer (NSCLC) resistance to some …