[HTML][HTML] Enhancing autophagy in Alzheimer's disease through drug repositioning
Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …
aging of the global population. Unfortunately, drugs for treating AD have been largely …
The interaction between autophagy and JAK/STAT3 signaling pathway in tumors
J Xu, J Zhang, QF Mao, J Wu, Y Wang - Frontiers in Genetics, 2022 - frontiersin.org
Tumor is one of the important factors affecting human life and health in today's world, and
scientists have studied it extensively and deeply, among which autophagy and JAK/STAT3 …
scientists have studied it extensively and deeply, among which autophagy and JAK/STAT3 …
[HTML][HTML] Repurposing Drugs in Oncology (ReDO)—chloroquine and hydroxychloroquine as anti-cancer agents
C Verbaanderd, H Maes, MB Schaaf… - …, 2017 - ncbi.nlm.nih.gov
Chloroquine (CQ) and hydroxychloroquine (HCQ) are well-known 4-aminoquinoline
antimalarial agents. Scientific evidence also supports the use of CQ and HCQ in the …
antimalarial agents. Scientific evidence also supports the use of CQ and HCQ in the …
[HTML][HTML] 3, 5-Dicaffeoylquinic acid attenuates microglial activation-mediated inflammatory pain by enhancing autophagy through the suppression of MCP3/JAK2 …
J Park, Y Kim, C Lee, YT Kim - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Microglial activation in the spinal cord contributes to the development of inflammatory pain.
Monocyte chemotactic protein 3 (MCP3) can induce microglial activation, resulting in …
Monocyte chemotactic protein 3 (MCP3) can induce microglial activation, resulting in …
Phosphorylation of eukaryotic initiation factor-2α (eIF2α) in autophagy
The integrated stress response is characterized by the phosphorylation of eukaryotic
initiation factor-2α (eIF2α) on serine 51 by one out of four specific kinases (EIF2AK1 to 4) …
initiation factor-2α (eIF2α) on serine 51 by one out of four specific kinases (EIF2AK1 to 4) …
A brain proteomic signature of incipient Alzheimer's disease in young APOE ε4 carriers identifies novel drug targets
Aptamer-based proteomics revealed differentially abundant proteins in Alzheimer's disease
(AD) brains in the Baltimore Longitudinal Study of Aging and Religious Orders Study (mean …
(AD) brains in the Baltimore Longitudinal Study of Aging and Religious Orders Study (mean …
Increased autophagy is required to protect periodontal ligament stem cells from apoptosis in inflammatory microenvironment
Y An, W Liu, P Xue, Y Zhang… - Journal of Clinical …, 2016 - Wiley Online Library
Objective Autophagy, which provides a mechanism for turnover cellular organelles and
proteins through a lysosome‐dependent degradation pathway, has been related to the …
proteins through a lysosome‐dependent degradation pathway, has been related to the …
The role of endolysosomal trafficking in anticancer drug resistance
Multidrug resistance (MDR) remains a major obstacle towards curative treatment of cancer.
Despite considerable progress in delineating the basis of intrinsic and acquired MDR, the …
Despite considerable progress in delineating the basis of intrinsic and acquired MDR, the …
Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways
L Varisli, O Cen, S Vlahopoulos - Immunology, 2020 - Wiley Online Library
Chloroquines are 4‐aminoquinoline‐based drugs mainly used to treat malaria. At
pharmacological concentrations, they have significant effects on tissue homeostasis …
pharmacological concentrations, they have significant effects on tissue homeostasis …
STAT3-targeted treatment with silibinin overcomes the acquired resistance to crizotinib in ALK-rearranged lung cancer
The signal transducer and activator of transcription 3 (STAT3) has been suggested to play a
prominent role in mediating non–small-cell lung cancer (NSCLC) resistance to some …
prominent role in mediating non–small-cell lung cancer (NSCLC) resistance to some …