How can we identify parasite genes that underlie antimalarial drug resistance?
T Anderson, S Nkhoma, A Ecker, D Fidock - Pharmacogenomics, 2011 - Taylor & Francis
This article outlines genome-scale approaches that can be used to identify mutations in
malaria (Plasmodium) parasites that underlie drug resistance and contribute to treatment …
malaria (Plasmodium) parasites that underlie drug resistance and contribute to treatment …
Local population structure of Plasmodium: impact on malaria control and elimination
Background Regardless of the growing interest in detecting population structures in malarial
parasites, there have been limited discussions on how to use this concept in control …
parasites, there have been limited discussions on how to use this concept in control …
Malaria life cycle intensifies both natural selection and random genetic drift
Analysis of genome sequences of 159 isolates of Plasmodium falciparum from Senegal
yields an extraordinarily high proportion (26.85%) of protein-coding genes with the ratio of …
yields an extraordinarily high proportion (26.85%) of protein-coding genes with the ratio of …
Immune selection suppresses the emergence of drug resistance in malaria parasites but facilitates its spread
Although drug resistance in Plasmodium falciparum typically evolves in regions of low
transmission, resistance spreads readily following introduction to regions with a heavier …
transmission, resistance spreads readily following introduction to regions with a heavier …
Bias-corrected maximum-likelihood estimation of multiplicity of infection and lineage frequencies
M Hashemi, KA Schneider - PloS one, 2021 - journals.plos.org
Background The UN's Sustainable Development Goals are devoted to eradicate a range of
infectious diseases to achieve global well-being. These efforts require monitoring disease …
infectious diseases to achieve global well-being. These efforts require monitoring disease …
Differences in selective pressure on dhps and dhfr drug resistant mutations in western Kenya
AM McCollum, KA Schneider, SM Griffing, Z Zhou… - Malaria journal, 2012 - Springer
Background Understanding the origin and spread of mutations associated with drug
resistance, especially in the context of combination therapy, will help guide strategies to halt …
resistance, especially in the context of combination therapy, will help guide strategies to halt …
Evolutionary genetics of malaria
KA Schneider, CJ Salas - Frontiers in Genetics, 2022 - frontiersin.org
Many standard-textbook population-genetic results apply to a wide range of species.
Sometimes, however, population-genetic models and principles need to be tailored to a …
Sometimes, however, population-genetic models and principles need to be tailored to a …
The Impact of Antimalarial Use on the Emergence and Transmission of Plasmodium falciparum Resistance: A Scoping Review of Mathematical Models
The emergence and transmission of resistance to antimalarial treatments continue to
hamper malaria elimination efforts. A scoping review was undertaken regarding the impact …
hamper malaria elimination efforts. A scoping review was undertaken regarding the impact …
Chloroquine efficacy studies confirm drug susceptibility of Plasmodium vivax in Chennai, India
Abstract Background Assessing the Plasmodium vivax burden in India is complicated by the
potential threat of an emerging chloroquine (CQ) resistant parasite population from …
potential threat of an emerging chloroquine (CQ) resistant parasite population from …
Charles Darwin meets Ronald Ross: a population-genetic framework for the evolutionary dynamics of malaria
KA Schneider - Infectious Diseases and Our Planet, 2021 - Springer
Malaria is a resilient disease characterized by complex life histories of the pathogen and the
vector, and still is a major threat to global development. We introduce a population-genetic …
vector, and still is a major threat to global development. We introduce a population-genetic …