With the nucleus as an exception, mitochondria are the only animal cell organelles
containing their own genetic information, called mitochondrial DNA (mtDNA). During oocyte …

Epigenetic modifications of the nuclear genome, including DNA methylation, histone
modifications and non-coding RNA post-transcriptional regulation, are increasingly being …

Mitochondria, known for more than a century as the energy powerhouse of a cell, represent
key intracellular signaling hub that are emerging as important determinants of several …

Mammalian genes were long thought to be constrained within somatic cells in most cell
types. This concept was challenged recently when cellular organelles including …

Cardiovascular diseases are among the leading causes of death worldwide. Reactive
oxygen species (ROS) can act as damaging molecules but also represent central hubs in …

Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …

Mitochondria are controlled by the coordination of two genomes: the mitochondrial and the
nuclear DNA. As such, variations in nuclear gene expression as a consequence of …

The mitochondrial genome has been difficult to manipulate because it is shielded by the
organelle double membranes, preventing efficient nucleic acid entry. Moreover …

Mitochondria are involved in a number of diverse cellular functions, including energy
production, metabolic regulation, apoptosis, calcium homeostasis, cell proliferation, and …

Most research to date has focused on epigenetic modifications in the nuclear genome, with
little attention devoted to mitochondrial DNA (mtDNA). Placental mtDNA content has been …