Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

Damage to our genetic material is an ongoing threat to both our ability to faithfully transmit
genetic information to our offspring as well as our own survival. To respond to these threats …

Mitochondrial DNA (mtDNA) copy number is a critical component of overall mitochondrial
health. In this chapter, we describe methods for isolation of both mtDNA and nuclear DNA …

Mitochondria are highly mobile and dynamic organelles that continually fuse and divide.
These processes allow mitochondria to exchange contents, including mitochondrial DNA …

The meaning of the word mitochondrion (from the Greek mitos, meaning thread, and
chondros, grain) illustrates that the heterogeneity of mitochondrial morphology has been …

Mitochondrial components, including mitochondrial DNA (mtDNA), when released
extracellularly, can act as “damage‐associated molecular pattern”(DAMP) agents and cause …

Defects of mitochondrial metabolism cause a wide range of human diseases that include
examples from all medical subspecialties. This review updates the topic of mitochondrial …

Mitochondrial diseases involve the respiratory chain, which is under the dual control of
nuclear and mitochondrial DNA (mtDNA). The complexity of mitochondrial genetics provides …

Mitochondrial dysfunction is heavily implicated in the multifactorial aging process. Aging
humans have increased levels of somatic mtDNA mutations that tend to undergo clonal …

Additional neurological features have recently been described in seven families transmitting
pathogenic mutations in OPA1, the most common cause of autosomal dominant optic …