Bionanotechnology has now become firmly established in its own right as one of the
principle and focused subdisciplines within nanotechnology.(1-10) Bionanotechnology can …

1. DENDRIMERS AND GENE DELIVERY Gene therapy represents a promising option for
the treatment of diseases such as inherited disorders, viral infections, and cancers. 1− 3 A …

While all the siRNA drugs on the market target the liver, the lungs offer a variety of currently
undruggable targets which could potentially be treated with RNA therapeutics. Hence, local …

Abstract Recently, United States Food and Drug Administration (FDA) and European
Commission (EC) approved Alnylam Pharmaceuticals' RNA interference (RNAi) therapeutic …

Chemotherapy is the first choice in the treatment of cancer and is always preferred to other
approaches such as radiation and surgery, but it has never met the need of patients for a …

Amphiphilic polymeric nanostructures have long been well-recognized as an excellent
candidate for drug delivery applications. With the recent advances in the “top-down” and …

Despite being engineered to avoid renal clearance, many cationic polymer (polycation)-
based siRNA nanoparticles that are used for systemic delivery are rapidly eliminated from …

It is a great challenge for nanomedicine to develop novel dendrimers with maximum
therapeutic potential and minimum side-effects for drug and gene delivery. As delivery …

Since the discovery of the “starburst polymer”, later renamed as dendrimer, this class of
polymers has gained considerable attention for numerous biomedical applications, due …

RNA interference (RNAi) is an efficient strategy to post‐transcriptionally silence gene
expression. While all siRNA drugs on the market target the liver, the lung offers a variety of …