Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain
The cerebral vascular system services the constant demand for energy during neuronal
activity in the brain. Attempts to delineate the logic of neurovascular coupling have been …
activity in the brain. Attempts to delineate the logic of neurovascular coupling have been …
Delivery of RNA interference
CX Li, A Parker, E Menocal, S Xiang, L Borodyansky… - Cell cycle, 2006 - Taylor & Francis
Over the last few years, RNA Interference (RNAi), a naturally occurring mechanism of gene
regulation conserved in plant and mammalian cells, has opened numerous novel …
regulation conserved in plant and mammalian cells, has opened numerous novel …
[HTML][HTML] In vivo reduction or blockade of interleukin-1β in primary osteoarthritis influences expression of mediators implicated in pathogenesis
KS Santangelo, GJ Nuovo, AL Bertone - Osteoarthritis and Cartilage, 2012 - Elsevier
OBJECTIVE: Diminish interleukin-1β (IL-1β) signaling in a model of primary osteoarthritis by
RNA interference-based transcript reduction or receptor blockade, and quantify changes …
RNA interference-based transcript reduction or receptor blockade, and quantify changes …
RNAi-mediated silencing of estrogen receptor α in the ventromedial nucleus of hypothalamus abolishes female sexual behaviors
Estrogen receptor α (ERα) plays a major role in the regulation of neuroendocrine functions
and behaviors by estrogens. Although the generation of ERα knockout mice advanced our …
and behaviors by estrogens. Although the generation of ERα knockout mice advanced our …
The increase of Nrf2 m6A modification induced by FTO downregulation promotes hippocampal neuron injury and aggravates the progression of epilepsy in a rat …
MQ Tian, J Li, XM Shu, CH Lang, J Chen, LY Peng… - Synapse, 2023 - Wiley Online Library
Epilepsy is a common chronic neurological disorder characterized by widespread neuronal
death. The purpose of this study was to investigate the role of nuclear factor erythroid 2 …
death. The purpose of this study was to investigate the role of nuclear factor erythroid 2 …
Induction of Robust Immune Responses against Human Immunodeficiency Virus Is Supported by the Inherent Tropism of Adeno-Associated Virus Type 5 forDendritic …
KQ Xin, H Mizukami, M Urabe, Y Toda… - Journal of …, 2006 - Am Soc Microbiol
The ability of adeno-associated virus serotype 1 to 8 (AAV1 to AAV8) vectors expressing the
human immunodeficiency virus type 1 (HIV-1) Env gp160 (AAV-HIV) to induce an immune …
human immunodeficiency virus type 1 (HIV-1) Env gp160 (AAV-HIV) to induce an immune …
Clinical and immunopathologic alterations in rhesus macaques affected with globoid cell leukodystrophy
Globoid cell leukodystrophy, or Krabbe's disease, is a severe disorder of the central and
peripheral nervous system caused by the absence of galactocerebrosidase (GALC) activity …
peripheral nervous system caused by the absence of galactocerebrosidase (GALC) activity …
Gene therapy progress and prospects–vectorology: design and production of expression cassettes in AAV vectors
C Le Bec, AM Douar - Gene therapy, 2006 - nature.com
Adeno-associated virus (AAV) derived vectors are considered highly eligible vehicles for
human gene therapy. Not only do they possess many great potential for clinical applications …
human gene therapy. Not only do they possess many great potential for clinical applications …
The Serine/threonine kinase Stk33 exhibits autophosphorylation and phosphorylates the intermediate filament protein Vimentin
B Brauksiepe, AO Mujica, H Herrmann, ER Schmidt - BMC biochemistry, 2008 - Springer
Abstract Background Colocalization of Stk33 with vimentin by double immunofluorescence
in certain cells indicated that vimentin might be a target for phosphorylation by the novel …
in certain cells indicated that vimentin might be a target for phosphorylation by the novel …
[HTML][HTML] Effective reduction of the interleukin-1β transcript in osteoarthritis-prone guinea pig chondrocytes via short hairpin RNA mediated RNA interference influences …
KS Santangelo, AL Bertone - Osteoarthritis and Cartilage, 2011 - Elsevier
OBJECTIVE: To ascertain a viral vector-based short hairpin RNA (shRNA) capable of
reducing the interleukin-1β (IL-1β) transcript in osteoarthritis (OA)-prone chondrocytes and …
reducing the interleukin-1β (IL-1β) transcript in osteoarthritis (OA)-prone chondrocytes and …