Genetics of common cerebral small vessel disease

C Bordes, M Sargurupremraj, A Mishra… - Nature Reviews …, 2022 - nature.com
Cerebral small vessel disease (cSVD) is a leading cause of ischaemic and haemorrhagic
stroke and a major contributor to dementia. Covert cSVD, which is detectable with brain MRI …

Mendelian randomization studies in stroke: exploration of risk factors and drug targets with human genetic data

MK Georgakis, D Gill - Stroke, 2021 - Am Heart Assoc
Elucidating the causes of stroke is key to developing effective preventive strategies. The
Mendelian randomization approach leverages genetic variants related to an exposure of …

Effects of selenium on chronic kidney disease: a mendelian randomization study

S Fu, L Zhang, F Ma, S Xue, T Sun, Z Xu - Nutrients, 2022 - mdpi.com
Background: Previous observational studies have shown that there is a controversial
association between selenium levels and chronic kidney disease (CKD). Our aim was to …

Mendelian randomization as a tool for causal inference in human nutrition and metabolism

SC Larsson - Current opinion in lipidology, 2021 - journals.lww.com
Mendelian randomization can be used as a tool to improve causal inference in
observational studies assessing the role of nutritional factors and metabolites in health and …

Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis

TA Pana, M Dehghani, HR Baradaran, SR Neal… - European journal of …, 2021 - Springer
The role of dietary calcium in cardiovascular disease prevention is unclear. We aimed to
determine the association between calcium intake and incident cardiovascular disease and …

Cardiovascular safety of calcium, magnesium and strontium: what does the evidence say?

EM Curtis, C Cooper, NC Harvey - Aging clinical and experimental …, 2021 - Springer
Calcium, magnesium and strontium have all been implicated in both musculoskeletal and
cardiovascular health and disease. However, despite these three elements being closely …

Serum calcium and 25-hydroxyvitamin D in relation to longevity, cardiovascular disease and cancer: a Mendelian randomization study

S Yuan, JA Baron, K Michaëlsson… - NPJ Genomic Medicine, 2021 - nature.com
Associations of serum calcium (S-Ca) and 25-hydroxyvitamin D (S-25 (OH) D)
concentrations with longevity, cardiovascular disease, and cancer are not clear. We …

Elevated calcium after acute ischemic stroke predicts severity and prognosis

Y Zhang, G Zhang, X Chen - Molecular Neurobiology, 2024 - Springer
The aim of this study is to investigate whether there is a correlation between serum calcium
levels and clinical severity or functional outcome at discharge in Chinese patients with acute …

Effects of glutamate and aspartate on prostate cancer and breast cancer: a Mendelian randomization study

Y Lin, Z Yang, J Li, Y Sun, X Zhang, Z Qu, Y Luo… - BMC genomics, 2022 - Springer
Abstract Background Respectively, prostate cancer (PCa) and breast cancer (BC) are the
second most and most commonly diagnosed cancer in men and women, and they account …

A mini review on the various facets effecting brain delivery of magnesium and its role in neurological disorders

AA Mathew, R Panonnummal - Biological Trace Element Research, 2023 - Springer
Magnesium is an essential cation present in the body that participates in the regulation of
various vital body functions. Maintaining normal level of magnesium is essential for proper …