Distant metastasis is a primary cause of mortality and contributes to poor surgical outcomes
in cancer patients. Before the development of organ-specific metastasis, the formation of a …

Liver cancer is a major global health concern, ranking among the top causes of cancer-
related deaths worldwide. Despite advances in medical research, the prognosis for liver …

The liver is a vital organ that continuously adapts to a wide and dynamic diversity of self-
antigens and xenobiotics. This involves the active contribution of immune cells, particularly …

Hepatocellular carcinoma is the predominant histologic variant of hepatic malignancy and
has become a major challenge to global health. The increasing incidence and mortality of …

The tumor microenvironment (TME) provides essential conditions for the occurrence,
invasion, and spread of cancer cells. Initial research has uncovered immunosuppressive …

A steady dysfunctional state caused by chronic antigen stimulation in the tumor
microenvironment (TME) is known as CD8+ T cell exhaustion. Exhausted-like CD8+ T cells …

T lymphocytes that infiltrate the tumor microenvironment (TME) often fail to function as
effective anti-cancer agents. Within the TME, cell-to-cell inhibitory interactions play …

The accumulation of pro-inflammatory senescent cells within tissues is a common hallmark
of the aging process and many age-related diseases. This modification has been called the …

The use of antitumor drugs represents a reliable strategy for cancer therapy. Unfortunately,
drug resistance has become increasingly common and contributes to tumor metastasis and …

Mammalian innate-like T cells (ILTCs), including mucosal-associated invariant T (MAIT),
natural killer T (NKT), and γδ T cells, are abundant tissue-resident lymphocytes that have …