Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell
lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils and …

The lung is highly exposed to the external environment. For this reason, the lung needs to
handle a number of potential threats present in inhaled air such as viruses or bacteria …

Despite the ongoing spread of MERS, there is limited knowledge of the factors affecting its
severity and outcomes. We analyzed clinical data and specimens from fourteen MERS …

Evidence has increasingly shown that the lungs are a major site of immune regulation. A
robust and highly regulated immune response in the lung protects the host from pathogen …

The release of cytokines from epithelial and stromal cells is critical for the initiation and
maintenance of tissue immunity. Three such cytokines, thymic stromal lymphopoietin, IL-33 …

Influenza virus infection induces a potent initial innate immune response, which serves to
limit the extent of viral replication and virus spread. However, efficient (and eventual) viral …

Secondary bacterial infections following influenza infection are a pressing problem facing
respiratory medicine. Although antibiotic treatment has been highly successful over recent …

Viral infections are a common cause of acute respiratory disease. The clinical course of
infection and symptoms depend on the viral strain, the health status of the host, and the …

The complexity of asthma is underscored by the number of cell types and mediators
implicated in the pathogenesis of this heterogeneous syndrome. Type 2 CD4+ T-cells (Th2) …

Influenza B viruses (IBV) cocirculate with influenza A viruses (IAV) and cause periodic
epidemics of disease, yet antibody and cellular responses following IBV infection are less …