Cancer is the second leading cause of death in the US. Current major treatments for cancer
management include surgery, cytotoxic chemotherapy, targeted therapy, radiation therapy …

Stimulation of almost all mammalian cell types leads to the release of cellular ATP and
autocrine feedback through a diverse array of purinergic receptors. Depending on the types …

Inappropriate or prolonged inflammation is the main cause of many diseases; for this reason
it is important to understand the physiological mechanisms that terminate inflammation in …

Human health is under constant threat of a wide variety of dangers, both self and nonself.
The immune system is occupied with protecting the host against such dangers in order to …

In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

Metabolic reprogramming and altered bioenergetics have emerged as hallmarks of cancer
and an area of active basic and translational cancer research. Drastically upregulated …

Extracellular adenosine 5'-triphosphate (eATP) is ubiquitously used for cell-tocell
communication. The low concentration of eATP ([eATP]) that exists in a “halo” surrounding …

Engagement of T cells with antigen-presenting cells requires T-cell receptor (TCR)
stimulation at the immune synapse. We previously reported that TCR stimulation induces the …

Extracellular ATP, at micromolar concentrations, induces significant functional changes in a
wide variety of cells and tissues. ATP can be released from the cytosol of damaged cells or …

Nucleotides are emerging as an ubiquitous family of extracellular signaling molecules. It has
been known for many years that adenosine diphosphate is a potent platelet aggregating …