Autophagy and inflammation

M Qian, X Fang, X Wang - Clinical and translational medicine, 2017 - Springer
Autophagy is a homeostatic mechanism involved in the disposal of damaged organelles,
denatured proteins as well as invaded pathogens through a lysosomal degradation …

[HTML][HTML] Autophagy in intracellular bacterial infection

W Hu, H Chan, L Lu, KT Wong, SH Wong, MX Li… - Seminars in cell & …, 2020 - Elsevier
Autophagy is a conserved intracellular degradation process enclosing the bulk of cytosolic
components for lysosomal degradation to maintain cellular homeostasis. Accumulating …

How to rewire the host cell: a home improvement guide for intracellular bacteria

E Cornejo, P Schlaermann, S Mukherjee - Journal of Cell Biology, 2017 - rupress.org
Intracellular bacterial pathogens have developed versatile strategies to generate niches
inside the eukaryotic cells that allow them to survive and proliferate. Making a home inside …

[HTML][HTML] Septin barriers protect mammalian host cells against Pseudomonas aeruginosa invasion

S Aigal, R Omidvar, K Stober, J Ziegelbauer, T Eierhoff… - Cell Reports, 2022 - cell.com
Septin GTPases polymerize into higher-ordered structures as a part of the cytoskeleton and
are involved in interactions of the host with a wide spectrum of pathogens. Many pathogens …

SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance

K Liu, L Kong, DB Graham, KL Carey, RJ Xavier - Cell reports, 2021 - cell.com
Phosphoinositides are important molecules in lipid signaling, membrane identity, and
trafficking that are spatiotemporally controlled by factors from both mammalian cells and …

The unsolved problem of how cells sense micron-scale curvature

KS Cannon, BL Woods, AS Gladfelter - Trends in biochemical sciences, 2017 - cell.com
Membrane curvature is a fundamental feature of cells and their organelles. Much of what we
know about how cells sense curved surfaces comes from studies examining nanometer …

[HTML][HTML] Mitochondrial dynamics: working with the cytoskeleton and intracellular organelles to mediate mechanotransduction

D Huang, S Chen, D Xiong, H Wang, L Zhu… - Aging and …, 2023 - ncbi.nlm.nih.gov
Cells are constantly exposed to various mechanical environments; therefore, it is important
that they are able to sense and adapt to changes. It is known that the cytoskeleton plays a …

The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis

CL Holley, S Emming, MM Monteleone… - Cell Chemical …, 2024 - cell.com
The Nod-like receptor protein 3 (NLRP3) inflammasome is activated by stimuli that induce
perturbations in cell homeostasis, which commonly converge on cellular potassium efflux …

Decoding post‐translational modifications of mammalian septins

K Sharma, MB Menon - Cytoskeleton, 2023 - Wiley Online Library
Septins are cytoskeletal GTPases that form nonpolar filaments and higher‐ordered
structures and they take part in a wide range of cellular processes. Septins are conserved …

Autophagic targeting and avoidance in intracellular bacterial infections

LJ Kohler, CR Roy - Current opinion in microbiology, 2017 - Elsevier
Highlights•Autophagy targets intracellular bacterial pathogens through multiple
mechanisms.•Bacterial strategies to avoid autophagy include motility and direct …