Molecular mechanisms of acquired antifungal drug resistance in principal fungal pathogens and EUCAST guidance for their laboratory detection and clinical …

TR Rogers, PE Verweij, M Castanheira… - Journal of …, 2022 - academic.oup.com
The increasing incidence and changing epidemiology of invasive fungal infections continue
to present many challenges to their effective management. The repertoire of antifungal drugs …

Pneumocystis infection in humans: diagnosis and treatment

EJ Calderón, S Gutiérrez-Rivero… - Expert review of anti …, 2010 - Taylor & Francis
Pneumocystis jirovecii is an atypical fungus exhibiting pulmonary tropism and a highly
defined host specificity. It is generally regarded as an opportunistic microorganism causing …

Nosocomial Pneumocystis jirovecii pneumonia: lessons from a cluster in kidney transplant recipients

LM Phipps, SCA Chen, K Kable, CL Halliday… - …, 2011 - journals.lww.com
Background. Pneumocystis jirovecii pneumonia (PJP) is an important infection-related
complication, whose mode of transmission remains uncertain. Methods. We investigated a …

[HTML][HTML] Clinical characteristics of Pneumocystis pneumonia in non-HIV patients and prognostic factors including microbiological genotypes

Y Matsumura, Y Shindo, Y Iinuma, M Yamamoto… - BMC infectious …, 2011 - Springer
Background The number of patients with non-HIV Pneumocystis pneumonia (PCP) is
increasing with widespread immunosuppressive treatment. We investigated the clinical …

[HTML][HTML] Update on Dihydropteroate Synthase (DHPS) Mutations in Pneumocystis jirovecii

C de la Horra, V Friaza, R Morilla, J Delgado… - Journal of Fungi, 2021 - mdpi.com
A Pneumocystis jirovecii is one of the most important microorganisms that cause pneumonia
in immunosupressed individuals. The guideline for treatment and prophylaxis of …

Internal Transcribed Spacer Region Sequence Heterogeneity in Rhizopus microsporus: Implications for Molecular Diagnosis in Clinical Microbiology Laboratories

PCY Woo, SY Leung, KKW To, JFW Chan… - Journal of clinical …, 2010 - Am Soc Microbiol
Although internal transcribed spacer region (ITS) sequence heterogeneity has been
reported in a few fungal species, it has very rarely been reported in pathogenic fungi and …

High Prevalence of Dihydropteroate Synthase Mutations in Pneumocystis jirovecii Isolated from Patients with Pneumocystis Pneumonia in South Africa

L Dini, M du Plessis, J Frean… - Journal of clinical …, 2010 - Am Soc Microbiol
Pneumocystis jirovecii pneumonia (PCP) is an important cause of morbidity and mortality in
immunocompromised patients. Sulfa-containing drugs are used for the treatment and …

Prevalence and genotype distribution of Pneumocystis jirovecii in Cuban infants and toddlers with whooping cough

EX Monroy-Vaca, Y de Armas… - Journal of clinical …, 2014 - Am Soc Microbiol
This study describes the prevalence and genotype distribution of Pneumocystis jirovecii
obtained from nasopharyngeal (NP) swabs from immunocompetent Cuban infants and …

Interhuman Transmission as a Potential Key Parameter for Geographical Variation in the Prevalence of Pneumocystis jirovecii Dihydropteroate Synthase Mutations

PM Hauser, A Nahimana, P Taffe… - Clinical Infectious …, 2010 - academic.oup.com
Background. Pneumocystis jirovecii dihydropteroate synthase (DHPS) mutations are
associated with failure of prophylaxis with sulfa drugs. This retrospective study sought to …

Low prevalence of DHFR and DHPS mutations in Pneumocystis jirovecii strains obtained from a German cohort

I Suárez, L Roderus, E van Gumpel, N Jung… - Infection, 2017 - Springer
Background Pneumocystis pneumonia (PCP) is an opportunistic and potentially life-
threatening infection of immunocompromised individuals. A combination of trimethoprim …