Surgical antimicrobial prophylaxis (SAP) is widely used to reduce the risk of surgical site
infections (SSI), but there is uncertainty as to what the proportion of SSI reduction is …

Surgical site infections (SSIs) are the most common adverse event occurring in surgical
patients. Optimal prevention of SSIs requires the bundled integration of a variety of …

Immediate drug-induced hypersensitivity reactions (IDHSRs) have conventionally been
attributed to an immunoglobulin E (IgE)–mediated mechanism. Nevertheless, it has now …

Study objective To compare the occurrence of cefazolin perioperative anaphylaxis (POA) in
patients with and without a penicillin allergy label (PAL) to determine whether the …

Objectives: This study sought to investigate the quality of antimicrobial prescribing among
adult surgical inpatients besides exploring the determinants of non-compliance and …

The aim of this study was to analyze the population pharmacokinetics of total and unbound
concentrations of prophylactic cefazolin (CFZ) in patients with prostatectomy or …

Abstract The Pharmacokinetic/Pharmacodynamic (PK/PD) relationship of antimicrobial
drugs (AMD) for surgical prophylaxis has been poorly studied, hampering evidence-based …

Background Vancomycin infusion reaction (VIR), reportedly mediated through Mas-Related
G Protein–Coupled Receptor-X2, is the primary vancomycin-induced immediate drug …

Background: Cefuroxime has played a crucial role in the prevention and treatment of
bacterial infections. However, the differences in adverse events across formulations and …

Background An appropriately administered surgical antimicrobial prophylaxis decreases the
rate of surgical site infections. Although evidence-based clinical practice guidelines have …