Autoregulation of serotonin neurons: role in antidepressant drug action

G Piñeyro, P Blier - Pharmacological reviews, 1999 - ASPET
The existence of an endogenous vasoconstrictor in blood serum (Stevens and Lee, 1984;
Brodie, 1900) and the presence in the gut of a substance that increases intestinal motility …

Role of Somatodendritic 5‐HT Autoreceptors in Modulating 5‐HT Neurotransmissiona

P Blier, G Pineyro, M El Mansari… - Annals of the New …, 1998 - Wiley Online Library
A very important element controlling serotonin (5‐HT) release throughout the brain is the 5‐
HT1A autoreceptor present on the soma and dendrites of 5‐HT neurons since it exerts a …

Increased anxiety of mice lacking the serotonin1A receptor

CL Parks, PS Robinson, E Sibille… - Proceedings of the …, 1998 - National Acad Sciences
Brain serotonin (5-HT) has been implicated in a number of physiological processes and
pathological conditions. These effects are mediated by at least 14 different 5-HT receptors …

5-HT1A receptor agonists: recent developments and controversial issues

J De Vry - Psychopharmacology, 1995 - Springer
During the last decade, serotonin (5-HT) 1A receptors have been a major target for
neurobiological research and drug development. 5-HT 1A receptors have been cloned and …

Early desensitization of somato-dendritic 5-HT1A autoreceptors in rats treated with fluoxetine or paroxetine

E Le Poul, N Laaris, E Doucet, AM Laporte… - Naunyn-Schmiedeberg's …, 1995 - Springer
Electrophysiological and autoradiographic approaches were used to assess possible
changes in 5-hydroxytryptamine (serotonin) 5-HT 1A receptors in the rat dorsal raphe …

5-HT1A receptor knockout mouse as a genetic model of anxiety

M Toth - European journal of pharmacology, 2003 - Elsevier
Low levels of the serotonin1A (5-HT1A) receptor have been repeatedly found in mood and
anxiety disorders. Stress often exacerbates psychiatric disease and can also reduce 5-HT1A …

Comparative Study of Pre-and Postsynaptic 5-HT1AReceptor Modulation of Anxiety in Two Ethological Animal Tests

SE File, LE Gonzalez, N Andrews - Journal of Neuroscience, 1996 - Soc Neuroscience
The purpose of this study was to determine the roles of the presynaptic 5-
hydroxytryptamine1A (5-HT1A) receptors in the median raphénucleus (MRN) and of the …

5-HT1A and benzodiazepine receptors in the basolateral amygdala modulate anxiety in the social interaction test, but not in the elevated plus-maze

LE Gonzalez, N Andrews, SE File - Brain research, 1996 - Elsevier
In order to investigate the role of the 5-HT1A receptors of the amygdala in modulating
anxiety, rats were implanted with bilateral cannulae aimed at the basolateral nucleus of the …

Rethinking 5-HT1A Receptors: Emerging Modes of Inhibitory Feedback of Relevance to Emotion-Related Behavior

SC Altieri, AL Garcia-Garcia, ED Leonardo… - ACS chemical …, 2013 - ACS Publications
The complexities of the involvement of the serotonin transmitter system in numerous
biological processes and psychiatric disorders is, to a substantial degree, attributable to the …

Genetic inactivation of the serotonin1A receptor in mice results in downregulation of major GABAA receptor α subunits, reduction of GABAA receptor binding, and …

E Sibille, C Pavlides, D Benke, M Toth - Journal of Neuroscience, 2000 - Soc Neuroscience
Anxiety is a common psychiatric illness often treated by benzodiazepines (BZs). BZs, such
as Valium, bind to the α subunit of the pentameric GABAA receptor and increase inhibition in …