We are witnessing a revolution in our understanding of primary aldosteronism (PA). In the
past 2 decades, we have learned that PA is a highly prevalent syndrome that is largely …

Early diagnosis and appropriate treatment of primary aldosteronism, the most frequent
cause of secondary hypertension, are crucial to prevent deleterious cardiovascular …

T-type, low-voltage activated, calcium channels, now designated Cav3 channels, are
involved in a wide variety of physiological functions, especially in nervous systems. Their …

The adrenal cortex produces dozens of steroids having varying degrees of glucocorticoid,
mineralocorticoid, and androgenic activity. Cortisol, the principal glucocorticoid, and …

Hypertension (HT) is a major cardiovascular risk factor that affects 10% to 40% of the
general population in an age-dependent manner. Detection of secondary forms of HT is …

Primary aldosteronism (PA) is the most common potentially curable form of hypertension.
The overproduction of aldosterone leads to an increased risk of cardiovascular and …

Aldosterone-producing adenomas with somatic mutations in the KCNJ5 G-protein–coupled
inwardly rectifying potassium channel are a cause of primary aldosteronism. These …

The syndromes of mineralocorticoid excess describe a heterogeneous group of clinical
manifestations leading to endocrine hypertension, typically either through direct activation of …

Research over the past 10 years has significantly improved our understanding of the
molecular pathogenesis of bilateral PA. Based on the improved understanding of BHA …

Primary aldosteronism is a common form of endocrine hypertension mainly caused by a
unilateral aldosterone-producing adenoma (APA) or bilateral adrenal hyperplasia (BAH) …