The role of the extracellular matrix protein TGFBI in cancer
A Corona, GC Blobe - Cellular signalling, 2021 - Elsevier
The secreted extracellular protein, transforming growth factor beta induced (TGFBI or
βIGH3), has roles in regulating numerous biological functions, including cell adhesion and …
βIGH3), has roles in regulating numerous biological functions, including cell adhesion and …
Transforming growth Factor-Beta-Induced Protein (TGFBI)/(βig-H3): a matrix protein with dual functions in ovarian cancer
Transforming growth factor-beta-induced protein (TGFBI, also known as βig-H3 and
keratoepithelin) is an extracellular matrix protein that plays a role in a wide range of …
keratoepithelin) is an extracellular matrix protein that plays a role in a wide range of …
Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma
MF Kaiser, DC Johnson, P Wu… - Blood, The Journal …, 2013 - ashpublications.org
Outcome in multiple myeloma is highly variable and a better understanding of the factors
that influence disease biology is essential to understand and predict behavior in individual …
that influence disease biology is essential to understand and predict behavior in individual …
TGFBI modulates tumour hypoxia and promotes breast cancer metastasis
F Fico, A Santamaria‐Martínez - Molecular oncology, 2020 - Wiley Online Library
Breast cancer metastasis is a complex process that depends not only on intrinsic
characteristics of metastatic stem cells, but also on the particular microenvironment that …
characteristics of metastatic stem cells, but also on the particular microenvironment that …
Epigenetic silencing of TGFBI confers resistance to trastuzumab in human breast cancer
S Palomeras, Á Diaz-Lagares, G Viñas, F Setien… - Breast Cancer …, 2019 - Springer
Background Acquired resistance to trastuzumab is a major clinical problem in the treatment
of HER2-positive (HER2+) breast cancer patients. The selection of trastuzumab-resistant …
of HER2-positive (HER2+) breast cancer patients. The selection of trastuzumab-resistant …
New models of hematogenous ovarian cancer metastasis demonstrate preferential spread to the ovary and a requirement for the ovary for abdominal dissemination
Emerging evidence suggest that many high-grade serous “ovarian” cancers (HGSOC) start
in the fallopian tube. Cancer cells are then recruited to the ovary and then spread diffusely …
in the fallopian tube. Cancer cells are then recruited to the ovary and then spread diffusely …
Enhanced expression of TGFBI promotes the proliferation and migration of glioma cells
SK Guo, MF Shen, HW Yao, YS Liu - Cellular Physiology and …, 2018 - karger.com
Abstract Background/Aims: Transforming growth factor beta-induced protein (TGFBI) is an
extracellular matrix protein induced by TGF-β. Previous studies have reported that the …
extracellular matrix protein induced by TGF-β. Previous studies have reported that the …
The role of TGFBI (βig-H3) in gastrointestinal tract tumorigenesis
B Han, H Cai, Y Chen, B Hu, H Luo, Y Wu, J Wu - Molecular cancer, 2015 - Springer
Background TGFβ-induced (TGFBI/βig-H3) is a protein inducible by TGFβ1 and secreted by
many types of cells. It binds to collagen, forms part of the extracellular matrix (ECM), and …
many types of cells. It binds to collagen, forms part of the extracellular matrix (ECM), and …
Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies
NS Nielsen, ET Poulsen, MV Lukassen… - Progress in Retinal and …, 2020 - Elsevier
Transforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the
second most abundant protein in the corneal stroma. In this review, we summarize the …
second most abundant protein in the corneal stroma. In this review, we summarize the …
Soluble TGFBI aggravates the malignancy of cholangiocarcinoma through activation of the ITGB1 dependent PPARγ signalling pathway
Background Cholangiocarcinoma is a devastating cancer with a poor prognosis. Previous
reports have presented conflicting results on the role of transforming growth factor-β-induced …
reports have presented conflicting results on the role of transforming growth factor-β-induced …