NETosis, an antimicrobial form of neutrophil cell death, is considered a primary source of
citrullinated autoantigens in rheumatoid arthritis (RA) and immunogenic DNA in systemic …

Oxidative stress is increased in systemic lupus erythematosus (SLE), and it contributes to
immune system dysregulation, abnormal activation and processing of cell-death signals …

Neutrophil extracellular traps (NETs) are implicated in autoimmunity, but how they are
generated and their roles in sterile inflammation remain unclear. Ribonucleoprotein immune …

Systemic lupus erythematosus (SLE) is a genetically complex autoimmune disease
characterized by loss of immune tolerance to nuclear and cell surface antigens. Previous …

Gout is characterized by an acute inflammatory reaction and the accumulation of neutrophils
in response to monosodium urate (MSU) crystals. Inflammation resolves spontaneously …

Highlights•Phagocyte NOX2 NADPH oxidase generates oxidants.•Optimal antimicrobial
action in phagosomes depends on oxidants.•Precise mechanisms of oxidant-dependent …

Reactive oxygen species (ROS) are created in cells during oxidative phosphorylation by the
respiratory chain in the mitochondria or by the family of NADPH oxidase (NOX) complexes …

The etiopathogenesis of systemic lupus erythematosus (SLE), a clinically heterogeneous
multisystemic syndrome that derives its name from the initial characterization of facial …

Systemic lupus erythematosus (SLE) is a genetically predisposed, female-predominant
disease, characterized by multiple organ damage, that in its most severe forms can be life …

The genome-wide association study is a free-hypothesis approach based on screening of
thousands or even millions of genetic variants distributed throughout the whole human …