Comprehensive review of targeted therapy for colorectal cancer

YH Xie, YX Chen, JY Fang - Signal transduction and targeted therapy, 2020 - nature.com
Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …

Overview of current targeted therapy in gallbladder cancer

X Song, Y Hu, Y Li, R Shao, F Liu, Y Liu - Signal Transduction and …, 2020 - nature.com
Gallbladder cancer (GBC) is rare, but is the most malignant type of biliary tract tumor.
Unfortunately, only a small population of cancer patients is acceptable for the surgical …

[PDF][PDF] YTHDF3 induces the translation of m6A-enriched gene transcripts to promote breast cancer brain metastasis

G Chang, L Shi, Y Ye, H Shi, L Zeng, S Tiwary, JT Huse… - Cancer cell, 2020 - cell.com
Brain metastasis is a major cause of cancer mortality, but its molecular mechanisms are
severely understudied. In addition, little is known regarding the role of m 6 A reader YTHDF3 …

Loss of XIST in breast cancer activates MSN-c-Met and reprograms microglia via exosomal miRNA to promote brain metastasis

F Xing, Y Liu, SY Wu, K Wu, S Sharma, YY Mo, J Feng… - Cancer research, 2018 - AACR
Up to 30% of patients with metastatic breast cancer eventually develop brain metastasis, yet
the pathologic mechanism behind this development remains poorly understood. Here, we …

[PDF][PDF] Metastasis organotropism: redefining the congenial soil

Y Gao, I Bado, H Wang, W Zhang, JM Rosen… - Developmental cell, 2019 - cell.com
Metastasis is the most devastating stage of cancer progression and causes the majority of
cancer-related deaths. Clinical observations suggest that most cancers metastasize to …

Feed‐forward loops between metastatic cancer cells and their microenvironment—the stage of escalation

Z Baumann, P Auf der Maur… - EMBO Molecular …, 2022 - embopress.org
Breast cancer is the most frequent cancer among women, and metastases in distant organs
are the leading cause of the cancer‐related deaths. While survival of early‐stage breast …

Type I interferon response in astrocytes promotes brain metastasis by enhancing monocytic myeloid cell recruitment

W Ma, MC Oliveira-Nunes, K Xu, A Kossenkov… - Nature …, 2023 - nature.com
Cancer metastasis to the brain is a significant clinical problem. Metastasis is the
consequence of favorable interactions between invaded cancer cells and the …

Polyunsaturated fatty acids from astrocytes activate PPARγ signaling in cancer cells to promote brain metastasis

Y Zou, A Watters, N Cheng, CE Perry, K Xu, GM Alicea… - Cancer Discovery, 2019 - AACR
Brain metastasis, the most lethal form of melanoma and carcinoma, is the consequence of
favorable interactions between the invading cancer cells and the brain cells. Peroxisome …

Emerging trends in colorectal cancer: Dysregulated signaling pathways

R Ahmad, JK Singh, A Wunnava… - International …, 2021 - spandidos-publications.com
Colorectal cancer (CRC) is the third most frequently detected type of cancer, and the second
most common cause of cancer‑related mortality globally. The American Cancer Society …

The evolving modern management of brain metastasis

PE Fecci, CD Champion, J Hoj, CM McKernan… - Clinical Cancer …, 2019 - AACR
The incidence of brain metastases is increasing as cancer therapies improve and patients
live longer, providing new challenges to the multidisciplinary teams that care for these …