ATP sensitive potassium channels (KATP) are so named because they open as cellular ATP
levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to …

1. Prologue 582. The Hodgkin–Huxley formalism for computing the action potential 592.1
The axon action potential model 592.2 Cardiac action potential models 623. Ion-channel …

The implementation of the ICH S7B and E14 guidelines has been successful in preventing
the introduction of potentially torsadogenic drugs to the market, but it has also unduly …

Background—Although pharmacological block of the slow, delayed rectifier potassium
current (I Ks) by chromanol 293B, L-735,821, or HMR-1556 produces little effect on action …

Background—Computational biology is a powerful tool for elucidating arrhythmogenic
mechanisms at the cellular level, where complex interactions between ionic processes …

A computational model of the human left-ventricular epicardial myocyte is presented. Models
of each of the major ionic currents present in these cells are formulated and validated using …

Background—The role of I Ks, the slow delayed rectifier K+ current, in cardiac ventricular
repolarization has been a subject of debate. Methods and Results—We develop a detailed …

Explanations for arrhythmia mechanisms at the cellular level are usually based on
experiments in nonhuman myocytes. However, subtle electrophysiological differences …

Local signaling domains and numerous interacting molecular pathways and substrates
contribute to the whole-cell response of myocytes during β-adrenergic stimulation (βARS) …

I Ks, the slowly activating component of the delayed rectifier current, plays a major role in
repolarization of the cardiac action potential (AP). Genetic mutations in the α-(KCNQ1) and β …