Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-developing
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …

Type 2 diabetes mellitus (T2DM) is a systemic disease characterized by hyperglycemia,
hyperlipidemia, and organismic insulin resistance. This pathological shift in both circulating …

DNA methylation is a major epigenetic mark with important roles in genetic regulation.
Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non …

Mitochondria retain bacterial traits due to their endosymbiotic origin, but host cells do not
recognize them as foreign because the organelles are sequestered. However, the regulated …

Epigenetic modifications of the nuclear genome, including DNA methylation, histone
modifications and non-coding RNA post-transcriptional regulation, are increasingly being …

Cytosolic nucleic acid sensors have a critical role in detecting endogenous nucleic acids to
initiate innate immune responses during microbial infections and/or cell death. Several …

Maintenance of the mitochondrial genome is essential for proper cellular function. For this
purpose, mitochondrial DNA (mtDNA) needs to be faithfully replicated, transcribed …

Forensic epigenetics, ie, investigating epigenetics variation to resolve forensically relevant
questions unanswerable with standard forensic DNA profiling has been gaining substantial …

Mitochondrial dysfunction plays critical roles in cancer development and related therapeutic
response; however, exact molecular mechanisms remain unclear. Recently, alongside the …