Mitochondrial permeability transition (mPT) is a phenomenon that abruptly causes the flux of
low molecular weight solutes (molecular weight up to 1,500) across the generally …

Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging
Zika virus, are an increasing and probably lasting global risk. This Review summarizes and …

In this review, we summarize current knowledge of perhaps one of the most intriguing
phenomena in cell biology: the mitochondrial permeability transition pore (mPTP). This …

Mitochondria are being recognized as key factors in many unexpected areas of biomedical
science. In addition to their well-known roles in oxidative phosphorylation and metabolism, it …

Covering: 2005 to 2007 Natural product and natural product-derived compounds that are
being evaluated in clinical trials or are in registration (as at 31st December 2007) have been …

Mitochondrial permeability transition, as the consequence of opening of a mitochondrial
permeability transition pore (mPTP), is a cellular catastrophe. Initiating bioenergetic collapse …

The mitochondrial permeability transition pore is a high conductance channel whose
opening leads to an increase of mitochondrial inner membrane permeability to solutes with …

In addition to their normal physiological role in ATP production and metabolism,
mitochondria exhibit a dark side mediated by the opening of a non-specific pore in the inner …

Ischemic heart disease is a significant cause of morbidity and mortality in Western society.
Although interventions, such as thrombolysis and percutaneous coronary intervention, have …

Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases,
including multiple cardiovascular disorders. However, translation of ROS scavengers …