Design and applications of water-soluble coordination cages

EG Percástegui, TK Ronson, JR Nitschke - Chemical Reviews, 2020 - ACS Publications
Compartmentalization of the aqueous space within a cell is necessary for life. In similar
fashion to the nanometer-scale compartments in living systems, synthetic water-soluble …

Protein assembly by design

J Zhu, N Avakyan, A Kakkis, AM Hoffnagle… - Chemical …, 2021 - ACS Publications
Proteins are nature's primary building blocks for the construction of sophisticated molecular
machines and dynamic materials, ranging from protein complexes such as photosystem II …

Protein cages: from fundamentals to advanced applications

TGW Edwardson, MD Levasseur, S Tetter… - Chemical …, 2022 - ACS Publications
Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …

Enzymatic noncovalent synthesis

H He, W Tan, J Guo, M Yi, AN Shy, B Xu - Chemical reviews, 2020 - ACS Publications
Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …

Peptide self-assembly through liquid-liquid phase separation

C Yuan, Q Li, R Xing, J Li, X Yan - Chem, 2023 - cell.com
Peptide self-assembly provides an innovative strategy for not only establishing an ideal
research model to understand life phenomena but also for constructing sophisticated …

De novo metalloprotein design

MJ Chalkley, SI Mann, WF DeGrado - Nature Reviews Chemistry, 2022 - nature.com
Natural metalloproteins perform many functions—ranging from sensing to electron transfer
and catalysis—in which the position and property of each ligand and metal are dictated by …

Hierarchical nanomaterials assembled from peptoids and other sequence-defined synthetic polymers

Z Li, B Cai, W Yang, CL Chen - Chemical Reviews, 2021 - ACS Publications
In nature, the self-assembly of sequence-specific biopolymers into hierarchical structures
plays an essential role in the construction of functional biomaterials. To develop synthetic …

Fluorescent sensors: A bright future for cages

A Brzechwa-Chodzyńska, W Drożdż… - Coordination Chemistry …, 2021 - Elsevier
This review provides a general overview of the development of fluorescent chemosensors
based on closed three-dimensional architectures and highlights selected examples from …

DNA-origami-directed virus capsid polymorphism

I Seitz, S Saarinen, EP Kumpula, D McNeale… - Nature …, 2023 - nature.com
Viral capsids can adopt various geometries, most iconically characterized by icosahedral or
helical symmetries. Importantly, precise control over the size and shape of virus capsids …

Precise assembly of proteins and carbohydrates for next-generation biomaterials

L Li, G Chen - Journal of the American Chemical Society, 2022 - ACS Publications
The complexity and diversity of biomacromolecules make them a unique class of building
blocks for generating precise assemblies. They are particularly available to a new …