In spite of the remarkable progress in basic and preclinical studies of acute myeloid
leukemia (AML), the five-year survival rate of AML patients remains poor, highlighting the …

Bone marrow mesenchymal stromal cells (BMSCs), identified as pericytes comprising the
hematopoietic niche, are a group of heterogeneous cells composed of multipotent stem …

Up to 18% of patients with acute myeloid leukemia (AML) present with a white blood cell
(WBC) count of greater than 100,000/µL, a condition that is frequently referred to as …

Mesenchymal stromal cells (MSCs) are essential elements of the bone marrow (BM)
microenvironment, which have been widely implicated in pathways that contribute to …

Self-renewal and multidirectional differentiation of hematopoietic stem cells (HSCs) are
strictly regulated by numerous cellular components and cytokines in the bone marrow (BM) …

Notch and Wnt signaling are highly conserved intercellular communication pathways
involved in developmental processes, such as hematopoiesis. Even though data from …

Chimeric antigen receptor (CAR) T cells targeting CD19 have been successful treating
patients with relapsed/refractory B cell acute lymphoblastic leukemia (ALL) and B cell …

Bone marrow (BM) is a highly complex tissue that provides important regulatory signals to
orchestrate hematopoiesis. Resident and transient cells occupy and interact with some well …

Purpose Here we review the current knowledge on bone marrow adipocytes (BMAds) as
active contributors to the regulation of the hematopoietic niche, and as potentially pivotal …

Human malignant hematopoietic stem and progenitor cells (HSPCs) reside in bone marrow
(BM) niches, which remain challenging to explore due to limited in vivo accessibility and …