Catch me if you can: how AML and its niche escape immunotherapy
S Tettamanti, A Pievani, A Biondi, G Dotti, M Serafini - Leukemia, 2022 - nature.com
In spite of the remarkable progress in basic and preclinical studies of acute myeloid
leukemia (AML), the five-year survival rate of AML patients remains poor, highlighting the …
leukemia (AML), the five-year survival rate of AML patients remains poor, highlighting the …
Bone marrow mesenchymal stromal cells: identification, classification, and differentiation
Q Gao, L Wang, S Wang, B Huang, Y Jing… - Frontiers in cell and …, 2022 - frontiersin.org
Bone marrow mesenchymal stromal cells (BMSCs), identified as pericytes comprising the
hematopoietic niche, are a group of heterogeneous cells composed of multipotent stem …
hematopoietic niche, are a group of heterogeneous cells composed of multipotent stem …
Hyperleukocytosis and leukostasis in acute myeloid leukemia: can a better understanding of the underlying molecular pathophysiology lead to novel treatments?
JP Bewersdorf, AM Zeidan - Cells, 2020 - mdpi.com
Up to 18% of patients with acute myeloid leukemia (AML) present with a white blood cell
(WBC) count of greater than 100,000/µL, a condition that is frequently referred to as …
(WBC) count of greater than 100,000/µL, a condition that is frequently referred to as …
Acute myeloid leukemia cells educate mesenchymal stromal cells toward an adipogenic differentiation propensity with leukemia promotion capabilities
L Zhang, Q Zhao, H Cang, Z Wang, X Hu… - Advanced …, 2022 - Wiley Online Library
Mesenchymal stromal cells (MSCs) are essential elements of the bone marrow (BM)
microenvironment, which have been widely implicated in pathways that contribute to …
microenvironment, which have been widely implicated in pathways that contribute to …
Hematopoietic stem cell niche during homeostasis, malignancy, and bone marrow transplantation
Y Man, X Yao, T Yang, Y Wang - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Self-renewal and multidirectional differentiation of hematopoietic stem cells (HSCs) are
strictly regulated by numerous cellular components and cytokines in the bone marrow (BM) …
strictly regulated by numerous cellular components and cytokines in the bone marrow (BM) …
The role of notch and wnt signaling in MSC communication in normal and leukemic bone marrow niche
P Takam Kamga, R Bazzoni, G Dal Collo… - Frontiers in cell and …, 2021 - frontiersin.org
Notch and Wnt signaling are highly conserved intercellular communication pathways
involved in developmental processes, such as hematopoiesis. Even though data from …
involved in developmental processes, such as hematopoiesis. Even though data from …
A bump in the road: how the hostile AML microenvironment affects CAR T cell therapy
Chimeric antigen receptor (CAR) T cells targeting CD19 have been successful treating
patients with relapsed/refractory B cell acute lymphoblastic leukemia (ALL) and B cell …
patients with relapsed/refractory B cell acute lymphoblastic leukemia (ALL) and B cell …
The bone marrow microenvironment mechanisms in acute myeloid leukemia
DB Pimenta, VA Varela, TS Datoguia… - Frontiers in Cell and …, 2021 - frontiersin.org
Bone marrow (BM) is a highly complex tissue that provides important regulatory signals to
orchestrate hematopoiesis. Resident and transient cells occupy and interact with some well …
orchestrate hematopoiesis. Resident and transient cells occupy and interact with some well …
[HTML][HTML] Bone marrow adiposity and the hematopoietic niche: A historical perspective of reciprocity, heterogeneity, and lineage commitment
J Tratwal, S Rojas-Sutterlin, C Bataclan, S Blum… - Best Practice & …, 2021 - Elsevier
Purpose Here we review the current knowledge on bone marrow adipocytes (BMAds) as
active contributors to the regulation of the hematopoietic niche, and as potentially pivotal …
active contributors to the regulation of the hematopoietic niche, and as potentially pivotal …
Culturing patient-derived malignant hematopoietic stem cells in engineered and fully humanized 3D niches
A García-García, T Klein, G Born… - Proceedings of the …, 2021 - National Acad Sciences
Human malignant hematopoietic stem and progenitor cells (HSPCs) reside in bone marrow
(BM) niches, which remain challenging to explore due to limited in vivo accessibility and …
(BM) niches, which remain challenging to explore due to limited in vivo accessibility and …