Obesity remains the most important risk factor for the incidence and progression of
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …

Metabolism is important for cartilage and synovial joint function. Under adverse
microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a …

Biomechanical factors play an important role in the health of diarthrodial joints. Altered joint
loading–associated to obesity, malalignment, trauma or joint instability–is a critical risk factor …

The most significant impact of obesity on the musculoskeletal system is associated with
osteoarthritis (OA), a disabling degenerative joint disorder characterized by pain, decreased …

Biomechanics plays a significant yet complex role in osteoarthritis (OA) onset and
progression. Identifying alterations in biomechanical factors and their complex interactions is …

Osteoarthritis (OA) is a chronic joint disease caused by disruption of joint homeostasis by a
variety of systemic and biomechanical factors. The disease is characterized by degradation …

Objective Test the hypothesis that greater baseline peak external knee adduction moment
(KAM), KAM impulse, and peak external knee flexion moment (KFM) during the stance …

The response of healthy and diseased cartilage of the knee to the mechanics of walking is
examined, with the goal of providing insight into the relationship between the kinematics and …

Obesity is associated with a range of disabling musculoskeletal conditions in adults. As the
prevalence of obesity increases, the societal burden of these chronic musculosketelal …

INTRODUCTION: Osteoarthritis (OA) of the knee joint is caused by genetic and hormonal
factors and by inflammation, in combination with biomechanical alterations. It is …