The purpose of this article is to review the ionic channels that have been characterized in
leukocytes and, whenever possible, to discuss their functional significance. This review …

Membrane receptors and ion transport mechanisms probably have an important role in
lymphocyte activation leading to T-lymphocyte proliferation in the immune response. Here …

Measurements have been made of cytoplasmic pH,(pHi) and free Mg2+
concentration,([Mg2+] i), in pig and mouse lymphocytes. pHi was measured in four ways: by …

Key points• Within cells, mitochondria oxidize carbohydrates, and fatty and amino acids to
use the released energy to form ATP, and in the process, they also generate reactive oxygen …

One of the best models for studying the control of mammalian cell growth and proliferation is
the response of lymphocytes to mitogenic agents1–4, which stimulate growth, DNA …

Human peripheral T lymphocytes were studied at 20‐24 degrees C using the gigaohm seal
recording technique in whole‐cell or outside‐out patch conformations. The predominant ion …

Ionic fluxes are thought to he involved in mediating the prolifer-ation of peripheral blood
lymphocytes (PBLs) in response to mitogenic substances1, 2. Among the earliest events …

Acidification of the cytosol of a number of different cell lines strongly reduced the endocytic
uptake of transferrin and epidermal growth factor. The number of transferrin binding sites at …

Similar to a variety of nucleated cells, human erythrocytes activate a non-selective cation
channel upon osmotic cell shrinkage. Further stimuli of channel activation include oxidative …

Over the past five years, patch-clamp recording has been used to characterize ion channels
expressed in several types of immune system cells, including T lymphocytes, B lymphocytes …