Human intestinal morphogenesis establishes 3D epithelial microarchitecture and spatially
organized crypt–villus characteristics. This unique structure is necessary to maintain …

Research in cell biology greatly relies on cell-based in vitro assays and models that facilitate
the investigation and understanding of specific biological events and processes under …

Over the last few years, the intestine has been extensively studied using in vitro microfluidic
systems, commonly known as gut-on-a-chip (GOC) devices. This interest has been due not …

Genome-wide association studies (GWAS) have now correlated hundreds of genetic
variants with complex genetic diseases and drug efficacy. Functional characterization of …

ABSTRACT A close symbiotic relationship exists between the intestinal microbiota and its
host. A critical component of gut homeostasis is the presence of a mucus layer covering the …

We leveraged a human gut-on-a-chip (Gut Chip) microdevice that enables independent
control of fluid flow and mechanical deformations to explore how physical cues and …

As a full-fidelity simulation of human cells, tissues, organs, and even systems at the
microscopic scale, Organ-on-a-Chip (OOC) has significant ethical advantages and …

Background The gut microbiome plays an important role in human health and disease.
Gnotobiotic animal and in vitro cell-based models provide some informative insights into …

Organ-on-a-chip (OOC) is a very ambitious emerging technology with a high potential to
revolutionize many medical and industrial sectors, particularly in preclinical-to-clinical …

Here, we report a pathomimetic Leaky Gut Chip that recapitulates increased epithelial
permeability and intestinal inflammation to assess probiotic intervention as live …