Parkinson's disease: Mechanisms, translational models and management strategies

C Raza, R Anjum - Life sciences, 2019 - Elsevier
Parkinson's disease is a progressive neurodegenerative disorder. The classical motor
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …

Animal models of Parkinson's disease

F Blandini, MT Armentero - The FEBS journal, 2012 - Wiley Online Library
Animal models of Parkinson's disease (PD) have been widely used in the past four decades
to investigate the pathogenesis and pathophysiology of this neurodegenerative disorder …

Bioinspired theranostic coordination polymer nanoparticles for intranasal dopamine replacement in Parkinson's disease

J García-Pardo, F Novio, F Nador, I Cavaliere… - ACS …, 2021 - ACS Publications
Dopamine (DA) is one of the main neurotransmitters found in the central nervous system
and has a vital role in the function of dopaminergic (DArgic) neurons. A progressive loss of …

Current screening methodologies in drug discovery for selected human diseases

OM Lage, MC Ramos, R Calisto, E Almeida… - Marine drugs, 2018 - mdpi.com
The increase of many deadly diseases like infections by multidrug-resistant bacteria implies
re-inventing the wheel on drug discovery. A better comprehension of the metabolisms and …

Cellular models of alpha‐synuclein toxicity and aggregation

M Delenclos, JD Burgess… - Journal of …, 2019 - Wiley Online Library
Misfolding and aggregation of alpha‐synuclein (α‐synuclein) with concomitant cytotoxicity is
a hallmark of Lewy body related disorders such as Parkinson's disease, dementia with Lewy …

Designable synthesis of a novel layered MXene loaded gold nanocluster composite for efficient electrochemical sensing of homocysteine in biological samples

F Liu, L Han, Y Yang, Z Xue, X Lu, X Liu - Chemical Engineering Journal, 2023 - Elsevier
The increased level of homocysteine (Hcy) becomes an independent risk factor for various
diseases. Quantification of Hcy is helpful to the early diagnosis and treatment of related …

Revisiting the paraquat-induced sporadic Parkinson's disease-like model

S Bastías-Candia, JM Zolezzi, NC Inestrosa - Molecular neurobiology, 2019 - Springer
Parkinson's disease (PD) is a major neurodegenerative disorder that affects 1–2% of the
total global population. Despite its high prevalence and publication of several studies …

Multifaces of neuropeptide Y in the brain–neuroprotection, neurogenesis and neuroinflammation

JO Malva, S Xapelli, S Baptista, J Valero, F Agasse… - Neuropeptides, 2012 - Elsevier
Neuropeptide Y (NPY) has been implicated in the modulation of important features of
neuronal physiology, including calcium homeostasis, neurotransmitter release and …

Chemically induced models of Parkinson's disease: history and perspectives for the involvement of ferroptosis

S Wen, T Aki, K Unuma, K Uemura - Frontiers in cellular …, 2020 - frontiersin.org
Ferroptosis is a newly discovered form of necrotic cell death characterized by its
dependency on iron and lipid peroxidation. Ferroptosis has attracted much attention recently …

Cell-based assays for Parkinson's disease using differentiated human LUHMES cells

X Zhang, M Yin, M Zhang - Acta Pharmacologica Sinica, 2014 - nature.com
Aim: Lund human mesencephalic (LUHMES) cells can be differentiated to post-mitotic cells
with biochemical, morphological and functional features of dopaminergic (DAergic) neurons …