Polycythemia vera (PV) is a hematopoietic stem cell neoplasm defined by activating somatic
mutations in the JAK2 gene and characterized clinically by overproduction of red blood cells …

Hepcidin is central to regulation of iron metabolism. Its effect on a cellular level involves
binding ferroportin, the main iron export protein, resulting in its internalization and …

Background Polycythemia vera is a chronic myeloproliferative neoplasm characterized by
erythrocytosis. Rusfertide, an injectable peptide mimetic of the master iron regulatory …

Abstract The JAK2 V617F and calreticulin mutations (CALR) are frequent within
myeloproliferative neoplasms (MPNs). JAK2 V617F has been detected in the general …

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders
characterized by activated Janus kinase (JAK)–signal transducer and activator of …

Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs), polycythemia
vera, essential thrombocythemia, and primary myelofibrosis, are hematopoietic stem cell …

Breast cancer is the most prevalent type of cancer among women. Several types of drugs,
targeting the specific proteins expressed on the breast cancer cell surface (such as receptor …

TMPRSS6 is a serine protease highly expressed in the liver. Its role in iron regulation was
first reported in 2008 when mutations in TMPRSS6 were shown to be the cause of iron …

Ferroptosis, a new type of regulated cell death, displays characteristics that transparently
differ from apoptosis, autophagy and necroptosis. There is growing appreciation that …

We reviewed current guidelines on the management of polycythemia vera. For questions
regarding the diagnostic investigation of erythrocytosis and the utility of specific laboratory …