The transcriptional foundation of pluripotency
I Chambers, SR Tomlinson - 2009 - journals.biologists.com
A fundamental goal in biology is to understand the molecular basis of cell identity.
Pluripotent embryonic stem (ES) cell identity is governed by a set of transcription factors …
Pluripotent embryonic stem (ES) cell identity is governed by a set of transcription factors …
The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells
Regulatory T cells (Treg cells) are required for peripheral tolerance. Evidence indicates that
Treg cells can adopt specialized differentiation programs in the periphery that are controlled …
Treg cells can adopt specialized differentiation programs in the periphery that are controlled …
Novel Foxo1-dependent transcriptional programs control Treg cell function
Regulatory T (Treg) cells, characterized by expression of the transcription factor forkhead
box P3 (Foxp3), maintain immune homeostasis by suppressing self-destructive immune …
box P3 (Foxp3), maintain immune homeostasis by suppressing self-destructive immune …
High-throughput methods for the analysis of transcription factors and chromatin modifications: Low input, single cell and spatial genomic technologies
M Salma, C Andrieu-Soler, V Deleuze… - Blood Cells, Molecules …, 2023 - Elsevier
Genome-wide analysis of transcription factors and epigenomic features is instrumental to
shed light on DNA-templated regulatory processes such as transcription, cellular …
shed light on DNA-templated regulatory processes such as transcription, cellular …
PRC2 directly methylates GATA4 and represses its transcriptional activity
A He, X Shen, Q Ma, J Cao, A von Gise… - Genes & …, 2012 - genesdev.cshlp.org
Polycomb-repressive complex 2 (PRC2) promotes tissue-specific differentiation by
depositing trimethylated histone H3 Lys 27 (H3K27me3) epigenetic marks to silence ectopic …
depositing trimethylated histone H3 Lys 27 (H3K27me3) epigenetic marks to silence ectopic …
Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry
BICD2 is one of the two mammalian homologues of the Drosophila Bicaudal D, an
evolutionarily conserved adaptor between microtubule motors and their cargo that was …
evolutionarily conserved adaptor between microtubule motors and their cargo that was …
MAP7 family proteins regulate kinesin-1 recruitment and activation
PJ Hooikaas, M Martin, T Mühlethaler… - Journal of Cell …, 2019 - rupress.org
Kinesin-1 is responsible for microtubule-based transport of numerous cellular cargoes.
Here, we explored the regulation of kinesin-1 by MAP7 proteins. We found that all four …
Here, we explored the regulation of kinesin-1 by MAP7 proteins. We found that all four …
Stage-specific control of early B cell development by the transcription factor Ikaros
The transcription factor Ikaros is an essential regulator of lymphopoiesis. Here we studied its
B cell–specific function by conditional inactivation of the gene encoding Ikaros (Ikzf1) in pro …
B cell–specific function by conditional inactivation of the gene encoding Ikaros (Ikzf1) in pro …
An integrated epigenomic and transcriptomic map of mouse and human αβ T cell development
Summary αβ lineage T cells, most of which are CD4+ or CD8+ and recognize MHC I-or MHC
II-presented antigens, are essential for immune responses and develop from CD4+ CD8+ …
II-presented antigens, are essential for immune responses and develop from CD4+ CD8+ …
Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease
How stage-specific enhancer dynamics modulate gene expression patterns essential for
organ development, homeostasis and disease is not well understood. Here, we addressed …
organ development, homeostasis and disease is not well understood. Here, we addressed …