Haemostasis stops bleeding at the site of vascular injury and maintains the integrity of blood
vessels through clot formation. This regulated physiological process consists of complex …

Antiplatelet agents and anticoagulants are a mainstay for the prevention and treatment of
thrombosis. However, despite advances in antithrombotic therapy, a fundamental challenge …

Background The global burden of type 2 diabetes mellitus (T2DM), together with the
presence of cardiovascular risk in this population, is reaching pandemic levels. A prominent …

Although platelets are best known for their role in hemostasis, they are also crucial in
development, host defense, inflammation, and tissue repair. Many of these roles are …

Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), also known as coronavirus
disease 2019 (COVID-19)-induced infection, is strongly associated with various …

Thrombo-inflammation describes the complex interplay between blood coagulation and
inflammation that plays a critical role in cardiovascular diseases. The third Maastricht …

Platelets rapidly undergo responsive transitions in form and function to repair vascular
endothelium and mediate hemostasis. In contrast, heterogeneous platelet subpopulations …

Platelets play a central role in arrest of bleeding. The ability of platelets to engage with
extracellular matrix proteins of the subendothelium has long been recognised as a pivotal …

COVID-19 infection is associated with a broad spectrum of presentations, but alveolar
capillary microthrombi have been described as a common finding in COVID-19 patients …

Impairment of vascular integrity is a hallmark of inflammatory diseases. We recently reported
that single immune-responsive platelets migrate and reposition themselves to sites of …