ROS-responsive microspheres for on demand antioxidant therapy in a model of diabetic peripheral arterial disease

KM Poole, CE Nelson, RV Joshi, JR Martin, MK Gupta… - Biomaterials, 2015 - Elsevier
A new microparticle-based delivery system was synthesized from reactive oxygen species
(ROS)-responsive poly (propylene sulfide)(PPS) and tested for “on demand” antioxidant …

Imaging of small animal peripheral artery disease models: recent advancements and translational potential

JB Lin, EH Phillips, TAE Riggins, GS Sangha… - International journal of …, 2015 - mdpi.com
Peripheral artery disease (PAD) is a broad disorder encompassing multiple forms of arterial
disease outside of the heart. As such, PAD development is a multifactorial process with a …

Automatic liver viability scoring with deep learning and hyperspectral imaging

E Felli, M Al-Taher, T Collins, R Nkusi, E Felli… - Diagnostics, 2021 - mdpi.com
Hyperspectral imaging (HSI) is a non-invasive imaging modality already applied to evaluate
hepatic oxygenation and to discriminate different models of hepatic ischemia. Nevertheless …

Drug-free ROS sponge polymeric microspheres reduce tissue damage from ischemic and mechanical injury

KP O'Grady, TE Kavanaugh, H Cho, H Ye… - ACS biomaterials …, 2017 - ACS Publications
The inherent antioxidant function of poly (propylene sulfide)(PPS) microspheres (MS) was
dissected for different reactive oxygen species (ROS), and therapeutic benefits of PPS-MS …

Cardiovascular imaging in mice

CKL Phoon, DH Turnbull - Current protocols in mouse biology, 2016 - Wiley Online Library
The mouse is the mammalian model of choice for investigating cardiovascular biology, given
our ability to manipulate it by genetic, pharmacologic, mechanical, and environmental …

Uncoupling angiogenesis and inflammation in peripheral artery disease with therapeutic peptide-loaded microgels

AL Zachman, X Wang, JM Tucker-Schwartz… - Biomaterials, 2014 - Elsevier
Peripheral artery disease (PAD) is characterized by vessel occlusion and ischemia in the
limbs. Treatment for PAD with surgical interventions has been showing limited success …

Mouse Cardiovascular Imaging

CKL Phoon, O Aristizábal, M Farhoud… - Current …, 2024 - Wiley Online Library
The mouse is the mammalian model of choice for investigating cardiovascular biology, given
our ability to manipulate it by genetic, pharmacologic, mechanical, and environmental …

Quantifying the vascular response to ischemia with speckle variance optical coherence tomography

KM Poole, DR McCormack, CA Patil… - Biomedical optics …, 2014 - opg.optica.org
Longitudinal monitoring techniques for preclinical models of vascular remodeling are critical
to the development of new therapies for pathological conditions such as ischemia and …

Experimental research on noninvasive reconstruction of optical parameter fields based on transient radiative transfer equation for diagnosis applications

H Qi, FZ Zhao, YT Ren, YB Qiao, LY Wei… - Journal of Quantitative …, 2019 - Elsevier
The noninvasive reconstruction of optical parameter fields in participating phantom is
investigated experimentally based on the measured time-resolved radiative signals, which …

Polymer assembly encapsulation of lanthanide nanoparticles as contrast agents for in vivo micro-CT

C Cruje, J Dunmore-Buyze, JP MacDonald… - …, 2018 - ACS Publications
Despite recent technological advancements in microcomputed tomography (micro-CT) and
contrast agent development, preclinical contrast agents are still predominantly iodine-based …