DNA methylation and cancer
M Kulis, M Esteller - Advances in genetics, 2010 - Elsevier
DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
In normal cells, it assures the proper regulation of gene expression and stable gene …
In normal cells, it assures the proper regulation of gene expression and stable gene …
Principles and challenges of genome-wide DNA methylation analysis
PW Laird - Nature Reviews Genetics, 2010 - nature.com
Methylation of cytosine bases in DNA provides a layer of epigenetic control in many
eukaryotes that has important implications for normal biology and disease. Therefore …
eukaryotes that has important implications for normal biology and disease. Therefore …
Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome
DNA methylation is the most studied epigenetic mark and CpG methylation is central to
many biological processes and human diseases. Since cancer has highlighted the …
many biological processes and human diseases. Since cancer has highlighted the …
Epigenetics in cancer
M Esteller - New England Journal of Medicine, 2008 - Mass Medical Soc
Gene transcription can be activated or inhibited by a reversible modification of the gene; this
modification is termed an epigenetic change. This account of epigenetics in cancer reviews …
modification is termed an epigenetic change. This account of epigenetics in cancer reviews …
Crosstalk between metabolic reprogramming and epigenetics in cancer: updates on mechanisms and therapeutic opportunities
T Ge, X Gu, R Jia, S Ge, P Chai… - Cancer …, 2022 - Wiley Online Library
Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …
Cancer epigenomics: beyond genomics
J Sandoval, M Esteller - Current opinion in genetics & development, 2012 - Elsevier
For many years cancer research has focused on genetic defects, but during the last decade
epigenetic deregulation has been increasingly recognized as a hallmark of cancer. The …
epigenetic deregulation has been increasingly recognized as a hallmark of cancer. The …
Cancer epigenomics: DNA methylomes and histone-modification maps
M Esteller - Nature reviews genetics, 2007 - nature.com
An altered pattern of epigenetic modifications is central to many common human diseases,
including cancer. Many studies have explored the mosaic patterns of DNA methylation and …
including cancer. Many studies have explored the mosaic patterns of DNA methylation and …
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
MF Fraga, E Ballestar, A Villar-Garea, M Boix-Chornet… - Nature …, 2005 - nature.com
CpG island hypermethylation and global genomic hypomethylation are common epigenetic
features of cancer cells. Less attention has been focused on histone modifications in cancer …
features of cancer cells. Less attention has been focused on histone modifications in cancer …
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus
Monozygotic (MZ) twins are partially concordant for most complex diseases, including
autoimmune disorders. Whereas phenotypic concordance can be used to study heritability …
autoimmune disorders. Whereas phenotypic concordance can be used to study heritability …
A DNA methylation fingerprint of 1628 human samples
AF Fernandez, Y Assenov, JI Martin-Subero… - Genome …, 2012 - genome.cshlp.org
Most of the studies characterizing DNA methylation patterns have been restricted to
particular genomic loci in a limited number of human samples and pathological conditions …
particular genomic loci in a limited number of human samples and pathological conditions …