The spatial and temporal organization of molecules within a cell is critical for coordinating
the many distinct activities carried out by the cell. In an increasing number of biological …

Contemporary analyses of cell metabolism have called out three metabolites: ATP, NADH,
and acetyl-CoA, as sentinel molecules whose accumulation represent much of the purpose …

Re-engineering enzymes with high activities in the given environments different from the
physiological one has been constantly pursued for application of enzymatic catalysis in …

Engineered metabolic pathways constructed from enzymes heterologous to the production
host often suffer from flux imbalances, as they typically lack the regulatory mechanisms …

Pyrimidine nucleotides play a critical role in cellular metabolism serving as activated
precursors of RNA and DNA, CDP-diacylglycerol phosphoglyceride for the assembly of cell …

Intracellular organization is a key factor in cell metabolism. Cells have evolved various
organizational systems to solve the challenges of toxic pathway intermediates, competing …

Acetyl-CoA carboxylase (ACC) catalyses the first committed step of fatty acid synthesis, the
carboxylation of acetyl-CoA to malonyl-CoA. Two physically distinct types of enzymes are …

The recent growth in protein databases has revealed the functional diversity of many protein
superfamilies. We have assessed the functional variation of homologous enzyme …

A metallocofactor containing iron, sulfur, copper, and nickel has been discovered in the
enzyme carbon monoxide dehydrogenase/acetyl-CoA (coenzyme A) synthase from …

Substrate channeling is a process of transferring the product of one enzyme to an adjacent
cascade enzyme or cell without complete mixing with the bulk phase. Such phenomena can …