Transcription factor BACH1 in cancer: roles, mechanisms, and prospects for targeted therapy
D Hu, Z Zhang, X Luo, S Li, J Jiang, J Zhang, Z Wu… - Biomarker …, 2024 - Springer
Transcription factor BTB domain and CNC homology 1 (BACH1) belongs to the Cap 'n'Collar
and basic region Leucine Zipper (CNC-bZIP) family. BACH1 is widely expressed in …
and basic region Leucine Zipper (CNC-bZIP) family. BACH1 is widely expressed in …
Perspectives on Synthetic Protein Circuits in Mammalian Cells
Mammalian synthetic biology aims to engineer cellular behaviors for therapeutic
applications, such as enhancing immune cell efficacy against cancers or improving cell …
applications, such as enhancing immune cell efficacy against cancers or improving cell …
Adaptive DNA amplification of synthetic gene circuit opens a way to overcome cancer chemoresistance
Drug resistance continues to impede the success of cancer treatments, creating a need for
experimental model systems that are broad, yet simple, to allow the identification of …
experimental model systems that are broad, yet simple, to allow the identification of …
A systems-level analysis of the mutually antagonistic roles of RKIP and BACH1 in dynamics of cancer cell plasticity
Epithelial–mesenchymal transition (EMT) is an important axis of phenotypic plasticity—a
hallmark of cancer metastasis. Raf kinase-B inhibitor protein (RKIP) and BTB and CNC …
hallmark of cancer metastasis. Raf kinase-B inhibitor protein (RKIP) and BTB and CNC …
Optimizing a CRISPR-Cas13d gene circuit for tunable target RNA downregulation with minimal collateral RNA cutting
The invention of RNA-guided DNA cutting systems has revolutionized biotechnology. More
recently, RNA-guided RNA cutting by Cas13d entered the scene as a highly promising …
recently, RNA-guided RNA cutting by Cas13d entered the scene as a highly promising …
[HTML][HTML] ZNF131-BACH1 transcriptionally accelerates RAD51-dependent homologous recombination repair and therapy-resistance of non-small-lung cancer cells by …
M Fan, Q Liu, X Ma, Y Jiang, Y Wang, S Jia… - …, 2024 - pmc.ncbi.nlm.nih.gov
Rationale: Both bulk RNA-sequencing and GEO database upon chemotherapy to non-small
cell lung cancer (NSCLC) cells reveal that ZNF131 (Zinc Finger Protein 131) maybe a …
cell lung cancer (NSCLC) cells reveal that ZNF131 (Zinc Finger Protein 131) maybe a …
Design and Model-Driven Analysis of Synthetic Circuits with the Staphylococcus aureus Dead-Cas9 (sadCas9) as a Programmable Transcriptional Regulator in …
D De Marchi, R Shaposhnikov, S Gobaa… - ACS Synthetic …, 2024 - ACS Publications
Synthetic circuit design is crucial for engineering microbes that process environmental cues
and provide biologically relevant outputs. To reliably scale-up circuit complexity, the …
and provide biologically relevant outputs. To reliably scale-up circuit complexity, the …
Tunable, self-contained gene dosage control via proteolytic cleavage of CRISPR-Cas systems
Gene therapy holds great therapeutic potential. Yet, controlling cargo expression in single
cells is limited due to the variability of delivery methods. We implement an incoherent …
cells is limited due to the variability of delivery methods. We implement an incoherent …
Synthetic Gene Circuits as a Promising Approach in Cancer Immunotherapy
B Ananthakumar, N Nanjundeshwara… - Critical Developments …, 2024 - igi-global.com
Cancer immunotherapy has emerged as a revolutionary approach in the fight against
cancer. Unlike traditional treatments like chemotherapy and radiation, immunotherapy …
cancer. Unlike traditional treatments like chemotherapy and radiation, immunotherapy …
Synthetic gene circuit evolution: Insights and opportunities at the mid-scale
Directed evolution focuses on optimizing single genetic components for predefined
engineering goals by artificial mutagenesis and selection. In contrast, experimental …
engineering goals by artificial mutagenesis and selection. In contrast, experimental …