Metformin—mode of action and clinical implications for diabetes and cancer
I Pernicova, M Korbonits - Nature Reviews Endocrinology, 2014 - nature.com
Metformin has been the mainstay of therapy for diabetes mellitus for many years; however,
the mechanistic aspects of metformin action remained ill-defined. Recent advances revealed …
the mechanistic aspects of metformin action remained ill-defined. Recent advances revealed …
[HTML][HTML] Glioma stem cells and their roles within the hypoxic tumor microenvironment
Tumor microenvironments are the result of cellular alterations in cancer that support
unrestricted growth and proliferation and result in further modifications in cell behavior …
unrestricted growth and proliferation and result in further modifications in cell behavior …
Roles of PFKFB3 in cancer
L Shi, H Pan, Z Liu, J Xie, W Han - Signal transduction and targeted …, 2017 - nature.com
Abstract The understanding of 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3
(PFK-2/FBPase 3, PFKFB3) has advanced considerably since its initial identification in …
(PFK-2/FBPase 3, PFKFB3) has advanced considerably since its initial identification in …
[HTML][HTML] Dysregulated metabolism contributes to oncogenesis
MD Hirschey, RJ DeBerardinis, AME Diehl… - Seminars in cancer …, 2015 - Elsevier
Cancer is a disease characterized by unrestrained cellular proliferation. In order to sustain
growth, cancer cells undergo a complex metabolic rearrangement characterized by changes …
growth, cancer cells undergo a complex metabolic rearrangement characterized by changes …
Role of PFKFB3 and PFKFB4 in cancer: genetic basis, impact on disease development/progression, and potential as therapeutic targets
Simple Summary Recently, our understanding of PFK-2 isozymes, particularly with regards
to their roles in cancer, has developed significantly. This review aims to compile the most …
to their roles in cancer, has developed significantly. This review aims to compile the most …
AMPK: a contextual oncogene or tumor suppressor?
J Liang, GB Mills - Cancer research, 2013 - AACR
The AMP-activated protein kinase (AMPK) functions to monitor and maintain energy
homeostasis at the cellular and organism level. AMPK was perceived historically primarily …
homeostasis at the cellular and organism level. AMPK was perceived historically primarily …
Glycometabolic rearrangements--aerobic glycolysis in pancreatic cancer: causes, characteristics and clinical applications
L Cao, J Wu, X Qu, J Sheng, M Cui, S Liu… - Journal of Experimental …, 2020 - Springer
Pancreatic cancer is one of the most malignant tumors worldwide, and pancreatic ductal
adenocarcinoma is the most common type. In pancreatic cancer, glycolysis is the primary …
adenocarcinoma is the most common type. In pancreatic cancer, glycolysis is the primary …
AMPK and Cancer
Z Wang, N Wang, P Liu, X Xie - AMP-activated protein kinase, 2016 - Springer
This chapter focuses on the role of AMPK as a stress-response molecule with an emphasis
on its duplex implication in carcinogenesis and cancer drug resistance. AMPK is closely …
on its duplex implication in carcinogenesis and cancer drug resistance. AMPK is closely …
Regulation and role of CAMKK2 in prostate cancer
TL Pulliam, P Goli, D Awad, C Lin… - Nature Reviews …, 2022 - nature.com
Abstract In 2011, CAMKK2, the gene encoding calcium/calmodulin-dependent kinase
kinase 2 (CAMKK2), was demonstrated to be a direct target of the androgen receptor and a …
kinase 2 (CAMKK2), was demonstrated to be a direct target of the androgen receptor and a …
Dual stimuli-responsive dynamic covalent peptide tags: toward sequence-controlled release in tumor-like microenvironments
MM Zegota, MA Müller, B Lantzberg… - Journal of the …, 2021 - ACS Publications
Dynamic covalent chemistry (DCvC) has emerged as a versatile synthetic tool for devising
stable, stimuli-responsive linkers or conjugates. The interplay of binding affinity, association …
stable, stimuli-responsive linkers or conjugates. The interplay of binding affinity, association …