Abstract Cardiomyocytes comprise∼ 70% to 85% of the total volume of the adult
mammalian heart but only about 25% to 35% of its total number of cells. Advances in single …

Exercise benefits the whole organism, yet, how tissues across the body orchestrally respond
to exercise remains enigmatic. Here, in young and old mice, with or without exercise, and …

Cardiovascular disease (CVD) has become a severe threat to human health, with morbidity
and mortality increasing yearly and gradually becoming younger. When the disease …

The study investigated the role of volunteer exercise and an obesogenic diet (OBD) in mice,
focusing on the splenocardiac axis and inflammation-resolution signaling. Male C57BL/6J …

Among its many cardiovascular benefits, exercise training improves heart function and
protects the heart against age-related decline, pathological stress, and injury. Here, we …

Progressive age-induced deterioration in the structure and function of the cardiovascular
system involves cardiac hypertrophy, diastolic dysfunction, myocardial fibrosis, arterial …

Age is among the most potent risk factors for developing heart failure and is strongly
associated with adverse outcomes. As the global population continues to age and the …

In Canada and worldwide, the elderly population (ie, individuals> 65 years of age) is
increasing disproportionately relative to the total population. This is expected to have a …

Coronary chronic total occlusion (CTO) contributes to the progression of heart failure in
patients with ischemic cardiomyopathy. Randomized controlled trials demonstrated that …

Significance: Heart failure is often accompanied by a decrease in the number of
cardiomyocytes. Although the adult mammalian hearts have limited regenerative capacity …