Insights into recent findings and clinical application of YAP and TAZ in cancer
Decades of research have mapped out the basic mechanics of the Hippo pathway. The
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …
Targeted therapy for head and neck cancer: signaling pathways and clinical studies
Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …
Activation of the EGFR/PI3K/AKT pathway limits the efficacy of trametinib treatment in head and neck cancer
O Novoplansky, AB Shnerb, D Marripati… - Molecular …, 2023 - Wiley Online Library
Blocking the mitogen‐activated protein kinase (MAPK) pathway with the MEK1/2 inhibitor
trametinib has produced promising results in patients with head and neck squamous cell …
trametinib has produced promising results in patients with head and neck squamous cell …
Statins in cancer prevention and therapy
N Ricco, SJ Kron - Cancers, 2023 - mdpi.com
Simple Summary Retrospective studies of common malignancies such as head and neck
cancer often report lower incidence and/or better outcomes for patients incidentally treated …
cancer often report lower incidence and/or better outcomes for patients incidentally treated …
How phosphofructokinase-1 promotes PI3K and YAP/TAZ in cancer: therapeutic perspectives
Simple Summary We propose that PFK1 promotes a positive feedback loop with PI3K/AKT
and YAP/TAZ signaling pathways in cancer cells. Therefore, targeting PFK1 (or its product F …
and YAP/TAZ signaling pathways in cancer cells. Therefore, targeting PFK1 (or its product F …
Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases
PD Talukdar, U Chatterji - Signal Transduction and Targeted Therapy, 2023 - nature.com
Specific cell states in metazoans are established by the symphony of gene expression
programs that necessitate intricate synergic interactions between transcription factors and …
programs that necessitate intricate synergic interactions between transcription factors and …
Multi-Functional Regulation by YAP/TAZ Signaling Networks in Tumor Progression and Metastasis
HL Thrash, AM Pendergast - Cancers, 2023 - mdpi.com
Simple Summary YAP and TAZ are both transcriptional co-activators in the Hippo pathway.
New evidence reveals that they have unique and overlapping functions during tumor …
New evidence reveals that they have unique and overlapping functions during tumor …
Malignant mesothelioma tumours: molecular pathogenesis, diagnosis, and therapies accompanying clinical studies
The pathetic malignant mesothelioma (MM) is a extremely uncommon and confrontational
tumor that evolves in the mesothelium layer of the pleural cavities (inner lining-visceral …
tumor that evolves in the mesothelium layer of the pleural cavities (inner lining-visceral …
EphA2 promotes the transcription of KLF4 to facilitate stemness in oral squamous cell carcinoma
J Bai, Y Chen, Y Sun, X Wang, Y Wang, S Guo… - Cellular and Molecular …, 2024 - Springer
Abstract Ephrin receptor A2 (EphA2), a member of the Ephrin receptor family, is closely
related to the progression of oral squamous cell carcinoma (OSCC). Cancer stem cells …
related to the progression of oral squamous cell carcinoma (OSCC). Cancer stem cells …
Genome-wide DNA methylation profiling of HPV-negative leukoplakia and gingivobuccal complex cancers
M Inchanalkar, S Srivatsa, S Ambatipudi, PG Bhosale… - Clinical …, 2023 - Springer
Background Gingivobuccal complex oral squamous cell carcinoma (GBC-OSCC) is an
aggressive malignancy with high mortality often preceded by premalignant lesions …
aggressive malignancy with high mortality often preceded by premalignant lesions …