Heart failure is a pressing worldwide public-health problem with millions of patients having
worsening heart failure. Despite all the available therapies, the condition carries a very poor …

Mitochondria are being recognized as key factors in many unexpected areas of biomedical
science. In addition to their well-known roles in oxidative phosphorylation and metabolism, it …

Mitochondria provide energy to the cell during aerobic respiration by supplying~ 95% of the
adenosine triphosphate (ATP) molecules via oxidative phosphorylation. These organelles …

BACKGROUND: Uric acid (UA) has proven to be a causal agent in endothelial dysfunction
in which ROS production plays an important role. Calcium overload in mitochondria can …

Ca2+ is a ubiquitous second messenger that plays an essential role in physiological
processes such as muscle contraction, neuronal secretion, and cell proliferation or …

A major manifestation of coronary artery disease is cardiac ischemia/reperfusion injury, with
the extent of injury directly relating to short-and long-term prognosis. Emerging evidence …

We describe the synthesis of gramine derivatives and their pharmacological evaluation as
multipotent drugs for the treatment of Alzheimer's disease. An innovative multitarget …

For the last two decades, most efforts on new drug development to treat Alzheimer's disease
have been focused to inhibit the synthesis of amyloid beta (Aβ), to prevent Aβ deposition, or …

CALHM1 is a Ca 2+ channel discovered in 2008, which plays a key role in the neuronal
electrical activity, among other functions. However, there are no known efficient blockers …

The discovery that 1-methyl-4-phenylpyridinium (MPP+) selectively destroys dopaminergic
neurons and causes Parkinson's disease (PD) symptoms in mammals has strengthened the …