Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation
Extracorporeal membrane oxygenation (ECMO) is a form of prolonged cardiopulmonary
bypass used to temporarily sustain cardiac and/or respiratory function in critically ill patients …
bypass used to temporarily sustain cardiac and/or respiratory function in critically ill patients …
Pharmacokinetic alterations associated with critical illness
D Morales Castro, L Dresser, J Granton, E Fan - Clinical Pharmacokinetics, 2023 - Springer
Haemodynamic, metabolic, and biochemical derangements in critically ill patients affect
drug pharmacokinetics and pharmacodynamics making dose optimisation particularly …
drug pharmacokinetics and pharmacodynamics making dose optimisation particularly …
Electrochemical aptamer-based sensors for improved therapeutic drug monitoring and high-precision, feedback-controlled drug delivery
The electrochemical aptamer-based (E-AB) sensing platform appears to be a convenient
(rapid, single-step, and calibration-free) and modular approach to measure concentrations …
(rapid, single-step, and calibration-free) and modular approach to measure concentrations …
Vitamin C as prophylaxis and adjunctive medical treatment for COVID-19?
AF Feyaerts, W Luyten - Nutrition, 2020 - Elsevier
Severe acute respiratory syndrome coronavirus 2 causes the potentially fatal coronavirus
disease 2019 (COVID-19). Already during the outbreak of the severe acute respiratory …
disease 2019 (COVID-19). Already during the outbreak of the severe acute respiratory …
Real-Time, Seconds-resolved measurements of plasma methotrexate in situ in the living body
Dose-limiting toxicity and significant patient-to-patient pharmacokinetic variability often
render it difficult to achieve the safe and effective dosing of drugs. This is further …
render it difficult to achieve the safe and effective dosing of drugs. This is further …
Antibacterial dosing in intensive care: pharmacokinetics, degree of disease and pharmacodynamics of sepsis
JA Roberts, J Lipman - Clinical pharmacokinetics, 2006 - Springer
Abstract Treatment of sepsis remains a significant challenge with persisting high mortality
and morbidity. Early and appropriate antibacterial therapy remains an important intervention …
and morbidity. Early and appropriate antibacterial therapy remains an important intervention …
Pharmacokinetic changes in critical illness
Physiologic alterations are frequently evident in critically ill patients. These alterations can
significantly affect the pharmacokinetics of drugs used in this patient population …
significantly affect the pharmacokinetics of drugs used in this patient population …
Pharmacology of commonly used analgesics and sedatives in the ICU: benzodiazepines, propofol, and opioids
JW Devlin, RJ Roberts - Critical care clinics, 2009 - criticalcare.theclinics.com
Patients who are critically ill and on mechanical ventilation frequently require sedation and
analgesic therapy to optimize patient comfort, facilitate patient-ventilator synchrony, and …
analgesic therapy to optimize patient comfort, facilitate patient-ventilator synchrony, and …
Impaired target site penetration of β-lactams may account for therapeutic failure in patients with septic shock
C Joukhadar, M Frossard, BX Mayer… - Critical care …, 2001 - journals.lww.com
Objective Current guidelines for adjusting antimicrobial therapy regimens commonly are
based on drug concentrations measured in plasma. In septic patients, however, the …
based on drug concentrations measured in plasma. In septic patients, however, the …
Voriconazole metabolism is influenced by severe inflammation: a prospective study
A Veringa, M Ter Avest, LFR Span… - Journal of …, 2016 - academic.oup.com
Background During an infection or inflammation, several drug-metabolizing enzymes in the
liver are down-regulated, including cytochrome P450 iso-enzymes. Since voriconazole is …
liver are down-regulated, including cytochrome P450 iso-enzymes. Since voriconazole is …