Extracorporeal membrane oxygenation (ECMO) is a form of prolonged cardiopulmonary
bypass used to temporarily sustain cardiac and/or respiratory function in critically ill patients …

Haemodynamic, metabolic, and biochemical derangements in critically ill patients affect
drug pharmacokinetics and pharmacodynamics making dose optimisation particularly …

The electrochemical aptamer-based (E-AB) sensing platform appears to be a convenient
(rapid, single-step, and calibration-free) and modular approach to measure concentrations …

Severe acute respiratory syndrome coronavirus 2 causes the potentially fatal coronavirus
disease 2019 (COVID-19). Already during the outbreak of the severe acute respiratory …

Dose-limiting toxicity and significant patient-to-patient pharmacokinetic variability often
render it difficult to achieve the safe and effective dosing of drugs. This is further …

Abstract Treatment of sepsis remains a significant challenge with persisting high mortality
and morbidity. Early and appropriate antibacterial therapy remains an important intervention …

Physiologic alterations are frequently evident in critically ill patients. These alterations can
significantly affect the pharmacokinetics of drugs used in this patient population …

Patients who are critically ill and on mechanical ventilation frequently require sedation and
analgesic therapy to optimize patient comfort, facilitate patient-ventilator synchrony, and …

Objective Current guidelines for adjusting antimicrobial therapy regimens commonly are
based on drug concentrations measured in plasma. In septic patients, however, the …

Background During an infection or inflammation, several drug-metabolizing enzymes in the
liver are down-regulated, including cytochrome P450 iso-enzymes. Since voriconazole is …