The conceptual origins of ribosome specialization can be traced back to the earliest days of
molecular biology. Yet, this field has only recently begun to gather momentum, with …

Regulation of protein synthesis is a vital step in controlling gene expression, especially
during development. Over the last 10 years, it has become clear that rather than being …

Nanopore RNA sequencing shows promise as a method for discriminating and identifying
different RNA modifications in native RNA. Expanding on the ability of nanopore sequencing …

Ribosomes are complex ribozymes that interpret genetic information by translating
messenger RNA (mRNA) into proteins. Natural variation in ribosome composition has been …

Protein synthesis by ribosomes is critically important for gene expression in all cells.
Ribosomal RNAs (rRNAs) are marked by numerous chemical modifications. An abundant …

Ribosomes are perhaps the most critical macromolecular machine as they are tasked with
carrying out protein synthesis in cells. They are incredibly complex structures composed of …

Embryonic stem cells (ESCs) and adult stem cells (ASCs) possess the remarkable capacity
to self-renew while remaining poised to differentiate into multiple progenies in the context of …

Recent epitranscriptomics studies unravelled that ribosomal RNA (rRNA) 2′ O-methylation
is an additional layer of gene expression regulation highlighting the ribosome as a novel …

More than one hundred RNA modifications decorate the chemical and topological properties
of these ribose nucleotides, thereby executing their biological functions through post …

The precise mapping and quantification of the numerous RNA modifications that are present
in tRNAs, rRNAs, ncRNAs/miRNAs, and mRNAs remain a major challenge and a top priority …