Chitosan derivatives and their application in biomedicine

W Wang, Q Meng, Q Li, J Liu, M Zhou, Z Jin… - International journal of …, 2020 - mdpi.com
Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan
is insoluble in water and most organic solvents, which seriously limits both its application …

Niosomal drug delivery systems for ocular disease—Recent advances and future prospects

S Durak, M Esmaeili Rad, A Alp Yetisgin, H Eda Sutova… - Nanomaterials, 2020 - mdpi.com
The eye is a complex organ consisting of several protective barriers and particular defense
mechanisms. Since this organ is exposed to various infections, genetic disorders, and visual …

Natural polymers decorated MOF-MXene nanocarriers for co-delivery of doxorubicin/pCRISPR

N Rabiee, M Bagherzadeh, M Jouyandeh… - ACS applied bio …, 2021 - ACS Publications
A one-pot and facile method with assistance of high gravity was applied for the synthesis of
inorganic two-dimensional MOF-5 embedded MXene nanostructures. The innovative …

Nanocarrier‐mediated cytosolic delivery of biopharmaceuticals

W He, X Xing, X Wang, D Wu, W Wu… - Advanced functional …, 2020 - Wiley Online Library
Biopharmaceuticals have emerged to play a vital role in disease treatment and have shown
promise in the rapidly expanding pharmaceutical market due to their high specificity and …

[HTML][HTML] Gene therapy for retinal degenerative diseases: progress, challenges, and future directions

S Drag, F Dotiwala… - … Ophthalmology & Visual …, 2023 - tvst.arvojournals.org
Since long before the first approval of gene therapy for retinal disease, ocular gene therapy
has captured the hopes of patients, clinicians, and scientists alike. Indeed, the retina …

Multifunctional stimuli-responsive niosomal nanoparticles for co-delivery and co-administration of gene and bioactive compound: In vitro and in vivo studies

NA Abtahi, SM Naghib, SJ Ghalekohneh… - Chemical Engineering …, 2022 - Elsevier
This study aims to optimize niosomes for carrying and delivering the anticancer agents and
genes, simultaneously. We synthesized new cationic niosomal formulations containing …

Bruch's membrane: a key consideration with complement-based therapies for age-related macular degeneration

S Hammadi, N Tzoumas, M Ferrara… - Journal of Clinical …, 2023 - mdpi.com
The complement system is crucial for immune surveillance, providing the body's first line of
defence against pathogens. However, an imbalance in its regulators can lead to …

Self-assembling drug formulations with tunable permeability and biodegradability

G Gaynanova, L Vasileva, R Kashapov, D Kuznetsova… - Molecules, 2021 - mdpi.com
This review focuses on key topics in the field of drug delivery related to the design of
nanocarriers answering the biomedicine criteria, including biocompatibility, biodegradability …

Retinal organoids as models for development and diseases

X Zhang, W Wang, ZB Jin - Cell Regeneration, 2021 - Springer
The evolution of pluripotent stem cell-derived retinal organoids (ROs) has brought
remarkable opportunities for developmental studies while also presenting new therapeutic …

Recent advances in micro-and nano-drug delivery systems based on natural and synthetic biomaterials

M Harun-Or-Rashid, MN Aktar, MS Hossain, N Sarkar… - Polymers, 2023 - mdpi.com
Polymeric drug delivery technology, which allows for medicinal ingredients to enter a cell
more easily, has advanced considerably in recent decades. Innovative medication delivery …