Neoplastic transformation results in a wide variety of cellular alterations that impact the
growth, survival, and general behavior of affected tissue. Although genetic alterations …

BACKGROUND Male infertility affects> 20 million men worldwide and represents a major
health concern. Although multifactorial, male infertility has a strong genetic basis which has …

Malaria parasite infection is initiated by the mosquito-transmitted sporozoite stage, a highly
motile invasive cell that targets hepatocytes in the liver for infection. A promising approach to …

C-linked glycosylation is essential for the trafficking, folding and function of secretory and
transmembrane proteins involved in cellular communication processes. The tryptophan C …

Infertility, defined by the inability of conceiving a child after 1 year is estimated to concern
approximately 50 million couples worldwide. As the male gamete is readily accessible and …

Spermatozoa are polarized cells with a head and a flagellum joined by the connecting
piece. Head integrity is critical for normal sperm function, and head defects consistently lead …

Previous studies demonstrated importance of C-mannosylation for efficient protein secretion.
To study its impact on protein folding and stability, we analyzed both C-mannosylated and …

The cadherin (cdh) superfamily of adhesion molecules carry O-linked mannose (O-Man)
glycans at highly conserved sites localized to specific β-strands of their extracellular cdh …

C-Mannosylation is a post-translational modification of proteins in the endoplasmic
reticulum. Monomeric α-mannose is attached to specific Trp residues at the first Trp in the …

Skeletal muscle differentiation requires precisely coordinated transcriptional regulation of
diverse gene programs that ultimately give rise to the specialized properties of this cell type …