Two-pore domain K+ (K2P) channels give rise to leak (also called background) K+ currents.
The well-known role of background K+ currents is to stabilize the negative resting …

Potassium channels participate in many biological functions, from ion homeostasis to
generation and modulation of the electrical membrane potential. They are involved in a …

TRAAK channels, members of the two–pore domain K+ (potassium ion) channel family K2P,
are expressed almost exclusively in the nervous system and control the resting membrane …

The sensation of cold or heat depends on the activation of specific nerve endings in the skin.
This involves heat‐and cold‐sensitive excitatory transient receptor potential (TRP) channels …

Abstract Two-pore-domain K+ (K2P) channel subunits are made up of four transmembrane
segments and two pore-forming domains that are arranged in tandem and function as either …

Potassium channels are particularly important in determining the shape and duration of the
action potential, controlling the membrane potential, modulating hormone secretion …

Regulatory enzymes often have different roles in distinct subcellular compartments. Yet,
most drugs indiscriminately saturate the cell. Thus, subcellular drug-delivery holds promise …

The ability of vertebrates to detect and avoid damaging extremes of temperature depends on
activation of ion channels belonging to the thermo-TRP family. Injury or inflammation causes …

TREK-1 is the most studied background K 2P channel. Its main role is to control cell
excitability and maintain the membrane potential below the threshold of depolarization …

The second messenger cyclic adenosine monophosphate (cAMP), which is produced by
adenylyl cyclases following stimulation of G-protein-coupled receptors, exerts its effect …