As identified in previously published articles, including those published in this issue, the
detection of early cognitive impairment among older adult populations is worthy of …

Cerebral white matter hyperintensities (WMH), detected in vivo with magnetic resonance
imaging (MRI), are commonly used to assess cerebrovascular burden in cognitive …

Background Longitudinal investigations are needed to improve understanding of the
contributions of cerebral small vessel disease to the clinical manifestation of Alzheimer's …

Cerebral white matter lesions (WML) are common in the aging brain and are associated with
dementia and depression. They are associated with vascular risk factors and small vessel …

White matter lesions (WML) are common in brain aging and are associated with dementia.
We aimed to investigate whether oxidative DNA damage and occur in WML and in …

There is growing evidence that vascular health plays a significant role in the etiology of
clinical Alzheimer's disease (AD). Understanding the timing of vascular changes in relation …

Background Although there are studies investigating the pathologic origins of mild cognitive
impairment (MCI), they have revolved around comparisons to normal elderly individuals or …

Objectives: Increasing evidence has demonstrated that vascular risk factors (VRFs)
contribute to cognitive impairment in the elderly population. Prevention and administration of …

Memory decline is often among the first signs heralding the emergence of mild cognitive
impairment or dementia regardless of etiology. Despite its limited inclusion of memory …

Background Vascular mild cognitive impairment (VMCI) is a potentially transitional state
between normal aging and vascular dementia. The presence of macroscopic white matter …