Modeling Alzheimer's disease with iPSC-derived brain cells
Alzheimer's disease is a devastating neurodegenerative disorder with no cure. Countless
promising therapeutics have shown efficacy in rodent Alzheimer's disease models yet failed …
promising therapeutics have shown efficacy in rodent Alzheimer's disease models yet failed …
The amyloid-β oligomer hypothesis: beginning of the third decade
The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
Infiltrating CD8+ T cells exacerbate Alzheimer's disease pathology in a 3D human neuroimmune axis model
Brain infiltration of peripheral immune cells and their interactions with brain-resident cells
may contribute to Alzheimer's disease (AD) pathology. To examine these interactions, in the …
may contribute to Alzheimer's disease (AD) pathology. To examine these interactions, in the …
A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease
Alzheimer's disease (AD) is characterized by beta-amyloid accumulation, phosphorylated
tau formation, hyperactivation of glial cells, and neuronal loss. The mechanisms of AD …
tau formation, hyperactivation of glial cells, and neuronal loss. The mechanisms of AD …
The complexity of tau in Alzheimer's disease
NN Naseri, H Wang, J Guo, M Sharma, W Luo - Neuroscience letters, 2019 - Elsevier
Alzheimer's disease (AD) is characterized by two major pathological lesions in the brain,
amyloid plaques and neurofibrillary tangles (NFTs) composed mainly of amyloid-β (Aβ) …
amyloid plaques and neurofibrillary tangles (NFTs) composed mainly of amyloid-β (Aβ) …
Alzheimer's disease: experimental models and reality
E Drummond, T Wisniewski - Acta neuropathologica, 2017 - Springer
Experimental models of Alzheimer's disease (AD) are critical to gaining a better
understanding of pathogenesis and to assess the potential of novel therapeutic approaches …
understanding of pathogenesis and to assess the potential of novel therapeutic approaches …
Nuclear-import receptors reverse aberrant phase transitions of RNA-binding proteins with prion-like domains
RNA-binding proteins (RBPs) with prion-like domains (PrLDs) phase transition to functional
liquids, which can mature into aberrant hydrogels composed of pathological fibrils that …
liquids, which can mature into aberrant hydrogels composed of pathological fibrils that …
Induced pluripotent stem cells and their use in human models of disease and development
P Karagiannis, K Takahashi, M Saito… - Physiological …, 2019 - journals.physiology.org
The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …
[HTML][HTML] Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
A pathological hallmark of Alzheimer's disease (AD) is the deposition of amyloid-β (Aβ)
protein in the brain. Physical exercise has been shown to reduce Aβ burden in various AD …
protein in the brain. Physical exercise has been shown to reduce Aβ burden in various AD …
An air particulate pollutant induces neuroinflammation and neurodegeneration in human brain models
Abstract Fine particulate matter (PM2. 5), a major component among air pollutants,
highlights as a global health concern. Several epidemiological studies show the correlation …
highlights as a global health concern. Several epidemiological studies show the correlation …