This digest covers some of the most relevant progress in malaria drug discovery published
between 2010 and 2012. There is an urgent need to develop new antimalarial drugs. Such …

Thienopyrimidines are widely represented in the literature, mainly due to their structural
relationship with purine base such as adenine and guanine. This current review presents …

Despite a quarter-century of constructivist theorizing in the social sciences and humanities,
ethnic groups continue to be conceived as entities and cast as actors. Journalists …

In today's world of constant identification checks, it's difficult to recall that there was ever a
time when" proof of identity" was not a part of everyday life. And as anyone knows who has …

Open-access drug discovery provides a substantial resource for diseases primarily affecting
the poor and disadvantaged. The open-access Pathogen Box collection is comprised of …

Malaria is the most lethal parasitic infections in the world. To address the emergence of drug
resistance to current antimalarials, here we report the design and synthesis of new series of …

The Apicomplexa phylum comprises thousands of distinct intracellular parasite species,
including coccidians, haemosporidians, piroplasms, and cryptosporidia. These parasites are …

Abstract A series of thieno [2, 3-d] pyrimidine alkyne Mannich base derivatives (7a-e, 8a-e)
and thieno [2, 3-d] pyrimidine 1, 3, 4-oxadiazole derivatives (9a-e, 10a-e) have been …

Effective chemotherapy is essential for controlling malaria. However, resistance of
Plasmodium falciparum to existing antimalarial drugs has undermined attempts to control …

4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a pivotal enzyme in tocopherol and
plastoquinone synthesis and a potential target for novel herbicides. Thirty-five pyridine …