Interleukin-5 (IL-5) exerts a central pathogenic role in differentiation, recruitment, survival,
and degranulation of eosinophils. Indeed, during the last years, significant advances have …

Systemic type 2 inflammation encompassing T helper 2 (TH2)-type responses is emerging
as a unifying feature of both classically defined allergic diseases, such as asthma, and a …

Increases in eosinophil numbers are associated with infection and allergic diseases,
including asthma, but there is also evidence that eosinophils contribute to homeostatic …

The human eosinophil has long been thought to favorably influence innate mucosal
immunity but at times has also been incriminated in disease pathophysiology. Research into …

Eosinophils have been traditionally perceived as terminally differentiated cytotoxic effector
cells. Recent studies have profoundly altered this simplistic view of eosinophils and their …

Dendritic cells, macrophages and B cells are regarded as the classical antigen-presenting
cells of the immune system. However, in recent years, there has been a rapid increase in the …

Eosinophils in visceral adipose tissue (VAT) have been implicated in metabolic homeostasis
and the maintenance of alternatively activated macrophages (AAMs). The absence of …

The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …

The initiation of type 2 immune responses by the epithelial cell–derived cytokines IL-25, IL-
33 and TSLP has been an area of extensive research in the past decade. Such studies have …

Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …