Metabolites once considered solely in catabolism or anabolism turn out to have key
regulatory functions. Among these, the citric acid cycle intermediate succinate stands out …

G protein-coupled receptors (GPCRs) have originally been described as a family of
receptors activated by hormones, neurotransmitters, and other mediators. However, in …

SUCNR1 is an auto-and paracrine sensor of the metabolic stress signal succinate. Using
unsupervised molecular dynamics (MD) simulations (170.400 ns) and mutagenesis across …

Lactate released from skeletal muscle during high-intensity exercise gives rise to a surge in
circulating lactate-derived pseudo-dipeptide metabolites including N-lactoyl-phenylalanine …

Succinate, a citric acid cycle intermediate, serves important functions in energy homeostasis
and metabolic regulation. Extracellular succinate acts as a stress signal through succinate …

Background As a dual-function metabolite, succinate has emerged in cell function and plays
a key signaling role in linking mitochondrial function to other cellular functions. Succinate …

The TCA cycle intermediate metabolite 'succinate'has been proposed as an inflammatory
mediator, influencing autoimmunity and allergic reactions, through ligation to its sensing …

Cardiovascular disease (CVD) refers to a class of diseases related to the heart or blood
vessels that have high global incidence. Succinate is generally considered an important …

Cardiovascular diseases (CVDs), the leading cause of mortality and disability worldwide,
are largely caused by manifestations of atherosclerosis, a chronic inflammatory disease …

Immune cells undergo metabolic reprogramming upon exposure to inflammatory stimuli. The
immuneresponsive gene 1 (Irg1) encodes aconitate decarboxylase (Acod1), an enzyme that …