The dawn of the age of amino acid sensors for the mTORC1 pathway
RL Wolfson, DM Sabatini - Cell metabolism, 2017 - cell.com
The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell
growth that responds to a diverse set of environmental inputs, including amino acids. Over …
growth that responds to a diverse set of environmental inputs, including amino acids. Over …
Modulation of oxidative stress as an anticancer strategy
The regulation of oxidative stress is an important factor in both tumour development and
responses to anticancer therapies. Many signalling pathways that are linked to …
responses to anticancer therapies. Many signalling pathways that are linked to …
Additive manufacturing of polymer-derived ceramics
ZC Eckel, C Zhou, JH Martin, AJ Jacobsen, WB Carter… - Science, 2016 - science.org
The extremely high melting point of many ceramics adds challenges to additive
manufacturing as compared with metals and polymers. Because ceramics cannot be cast or …
manufacturing as compared with metals and polymers. Because ceramics cannot be cast or …
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
RA Saxton, KE Knockenhauer, RL Wolfson… - Science, 2016 - science.org
Eukaryotic cells coordinate growth with the availability of nutrients through the mechanistic
target of rapamycin complex 1 (mTORC1), a master growth regulator. Leucine is of particular …
target of rapamycin complex 1 (mTORC1), a master growth regulator. Leucine is of particular …
Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling
Reactive oxygen and nitrogen species change cellular responses through diverse
mechanisms that are now being defined. At low levels, they are signalling molecules, and at …
mechanisms that are now being defined. At low levels, they are signalling molecules, and at …
[HTML][HTML] The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a major regulator of cell
growth that responds to numerous environmental cues. A key input is amino acids, which act …
growth that responds to numerous environmental cues. A key input is amino acids, which act …
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
GE Hardingham, H Bading - Nature Reviews Neuroscience, 2010 - nature.com
There is a long-standing paradox that NMDA (N-methyl-d-aspartate) receptors (NMDARs)
can both promote neuronal health and kill neurons. Recent studies show that NMDAR …
can both promote neuronal health and kill neurons. Recent studies show that NMDAR …
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage
Sestrins (Sesns) protect cells from oxidative stress. The mechanism underlying the
antioxidant effect of Sesns has remained unknown, however. The Nrf2-Keap1 pathway …
antioxidant effect of Sesns has remained unknown, however. The Nrf2-Keap1 pathway …
SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages
MJ Kim, SH Bae, JC Ryu, Y Kwon, JH Oh, J Kwon… - Autophagy, 2016 - Taylor & Francis
Proper regulation of mitophagy for mitochondrial homeostasis is important in various
inflammatory diseases. However, the precise mechanisms by which mitophagy is activated …
inflammatory diseases. However, the precise mechanisms by which mitophagy is activated …
Sestrins orchestrate cellular metabolism to attenuate aging
The Sestrins constitute a family of evolutionarily conserved stress-inducible proteins that
suppress oxidative stress and regulate AMP-dependent protein kinase (AMPK)-mammalian …
suppress oxidative stress and regulate AMP-dependent protein kinase (AMPK)-mammalian …