To date, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has determined 399,600,607 cases and 5,757,562 …

In eukaryotes, poly (A) tails are present on almost every mRNA. Early experiments led to the
hypothesis that poly (A) tails and the cytoplasmic polyadenylate-binding protein (PABPC) …

The emerging" epitranscriptomics" field is providing insights into the biological and
pathological roles of different RNA modifications. The RNA methyltransferase METTL1 …

Background Degradation rate is a fundamental aspect of mRNA metabolism, and the factors
governing it remain poorly characterized. Understanding the genetic and biochemical …

Codon usage bias, the preference for certain synonymous codons, is found in all genomes.
Although synonymous mutations were previously thought to be silent, a large body of …

Messenger RNA (mRNA) stability and translational efficiency are two crucial aspects of the
post-transcriptional process that profoundly impact protein production in a cell. While it is …

INTRODUCTION The tightly controlled process of gene expression requires messenger
RNAs (mRNAs), which represent DNA-derived blueprints for polypeptides, to be translated …

The genetic code is degenerate, and most amino acids are encoded by two to six
synonymous codons. Codon usage bias, the preference for certain synonymous codons, is a …

Abstract mRNA surveillance pathways are essential for accurate gene expression and to
maintain translation homeostasis, ensuring the production of fully functional proteins. Future …

Readthrough into the 3′ untranslated region (3′ UTR) of the mRNA results in the
production of aberrant proteins. Metazoans efficiently clear readthrough proteins, but the …